Liu Lu, Chen Daohong, Zhou Ziyang, Yuan Jing, Chen Ying, Sun Mingsheng, Zhou Mengdi, Liu Yi, Sun Shiqi, Chen Jiao, Zhao Ling
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Acupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu, Sichuan, China.
Front Pharmacol. 2023 Mar 22;14:1138128. doi: 10.3389/fphar.2023.1138128. eCollection 2023.
Ischemic stroke has been a prominent focus of scientific investigation owing to its high prevalence, complex pathogenesis, and difficulties in treatment. Mitochondria play an important role in cellular energy homeostasis and are involved in neuronal death following ischemic stroke. Hence, maintaining mitochondrial function is critical for neuronal survival and neurological improvement in ischemic stroke, and mitochondria are key therapeutic targets in cerebral stroke research. With the benefits of high efficacy, low cost, and high safety, traditional Chinese medicine (TCM) has great advantages in preventing and treating ischemic stroke. Accumulating studies have explored the effect of TCM in preventing and treating ischemic stroke from the perspective of regulating mitochondrial structure and function. In this review, we discuss the molecular mechanisms by which mitochondria are involved in ischemic stroke. Furthermore, we summarized the current advances in TCM in preventing and treating ischemic stroke by modulating mitochondria. We aimed to provide a new perspective and enlightenment for TCM in the prevention and treatment of ischemic stroke by modulating mitochondria.
由于缺血性中风的高患病率、复杂的发病机制和治疗困难，它一直是科学研究的重点。线粒体在细胞能量稳态中起重要作用，并参与缺血性中风后的神经元死亡。因此，维持线粒体功能对于缺血性中风时神经元的存活和神经功能改善至关重要，线粒体是脑卒中研究中的关键治疗靶点。传统中药（TCM）具有高效、低成本和高安全性的优点，在预防和治疗缺血性中风方面具有很大优势。越来越多的研究从调节线粒体结构和功能的角度探讨了中药在预防和治疗缺血性中风方面的作用。在这篇综述中，我们讨论了线粒体参与缺血性中风的分子机制。此外，我们总结了中药通过调节线粒体预防和治疗缺血性中风的当前进展。我们旨在通过调节线粒体为中药预防和治疗缺血性中风提供新的视角和启示。
