Udomkiattikul Jutamas, Kirdratanasak Noppasorn, Siritianwanitchakul Panatsada, Worapunyaanun Wasaporn, Surachetpong Sirilak Disatian
Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University,Pathumwan, Thailand.
Int J Vet Sci Med. 2022 Apr 29;10(1):25-32. doi: 10.1080/23144599.2022.2067630. eCollection 2022.
Pulmonary hypertension (PH) is a common complication in dogs with degenerative mitral valve disease (DMVD). The aim of this study was to determine the survival time and to determine factors related to the survival time of dogs with PH secondary to DMVD stage C. A retrospective study was conducted in 37 dogs with PH secondary to DMVD stage C to analyse the median survival time and associated factors such as age, sex, breed, body weight, the presence of syncope, heart rate, systolic blood pressure, manifestation of congestive heart failure (CHF), vertebral heart score (VHS), the presence of left or right heart enlargement, probability of PH and medication. Data were analysed using the Log-Rank test and plotted with the Kaplan-Meier curve. The results showed that the median survival time of dogs with PH secondary to DMVD stage C was 368 days, and factors that shortened the median survival time of dogs with PH secondary to DMVD stage C were mixed breeds, VHS > 11.5, the presence of right heart enlargement, ascites and high probability of PH. Factors associated with an increased hazard of death were mixed breed dogs, dogs with right heart enlargement and ascites. These findings may be useful for the prognosis and management of dogs with PH secondary to DMVD stage C.
肺动脉高压（PH）是退行性二尖瓣疾病（DMVD）犬的常见并发症。本研究的目的是确定患有继发于C期DMVD的PH犬的生存时间，并确定与生存时间相关的因素。对37只患有继发于C期DMVD的PH犬进行了一项回顾性研究，以分析中位生存时间和相关因素，如年龄、性别、品种、体重、晕厥的存在、心率、收缩压、充血性心力衰竭（CHF）的表现、心脏椎体评分（VHS）、左或右心扩大的存在、PH的可能性和用药情况。使用对数秩检验分析数据，并用Kaplan-Meier曲线进行绘制。结果显示，患有继发于C期DMVD的PH犬的中位生存时间为368天，缩短患有继发于C期DMVD的PH犬中位生存时间的因素为混种犬、VHS>11.5、右心扩大的存在、腹水和PH的高可能性。与死亡风险增加相关的因素是混种犬、右心扩大和腹水的犬。这些发现可能对患有继发于C期DMVD的PH犬的预后和管理有用。
