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牙齿缺失抑制幼年斯普拉格-道利大鼠海马神经发生并导致认知功能障碍。

Tooth Loss Suppresses Hippocampal Neurogenesis and Leads to Cognitive Dysfunction in Juvenile Sprague-Dawley Rats.

作者信息

Hu Jiangqi, Wang Xiaoyu, Kong Wei, Jiang Qingsong

机构信息

Beijing Stomatological Hospital, Capital Medical University, Beijing, China.

Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Sciences, Beijing Institute of Technology, Beijing, China.

出版信息

Front Neurosci. 2022 Apr 28;16:839622. doi: 10.3389/fnins.2022.839622. eCollection 2022.

DOI:10.3389/fnins.2022.839622
PMID:35573291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9095951/
Abstract

BACKGROUND

Both animal studies and prospective observational studies on patients with neurodegenerative disease have reported a positive link between oral diseases and cognitive function. However, the effect of early tooth loss on hippocampal morphology remains unknown.

METHODS

In this study, 6-week-old, male, juvenile Sprague-Dawley (SD) rats were randomized into the control (C) and tooth loss (TL) groups. In the TL group, all right maxillary molars of SD rats were extracted, while in the C group, no teeth were extracted. After 3 months, the learning and memory behavior were examined by Morris Water Maze (MWM), and the protein expression and mechanic signaling pathways were analyzed by real-time polymerase chain reaction, and cresyl violet staining.

RESULTS

Two days after the operation, the body weight of both groups recovered and gradually returned to the level before operation. Three months after tooth extraction, the completion time of the C group in the MWM was significantly shorter than the TL group. The mRNA expression of , and in the C group were significantly higher than in the TL group. The pyramidal neurons in the TL group was fewer than in the C group.

CONCLUSION

Tooth loss in the juvenile SD rats will reduce the number of pyramidal neurons in the hippocampus, inhibit the expression of , and , and eventually lead to cognitive dysfunction.

摘要

背景

关于神经退行性疾病患者的动物研究和前瞻性观察研究均报告了口腔疾病与认知功能之间存在正相关。然而，早期牙齿缺失对海马形态的影响仍不清楚。

方法

在本研究中，将6周龄的雄性幼年Sprague-Dawley（SD）大鼠随机分为对照组（C）和牙齿缺失组（TL）。在TL组中，拔除SD大鼠的所有右上颌磨牙，而在C组中，未拔牙。3个月后，通过莫里斯水迷宫（MWM）检测学习和记忆行为，并通过实时聚合酶链反应和甲酚紫染色分析蛋白质表达和机械信号通路。

结果

术后两天，两组体重均恢复并逐渐恢复到术前水平。拔牙3个月后，C组在MWM中的完成时间明显短于TL组。C组中 、 和 的mRNA表达明显高于TL组。TL组中的锥体神经元少于C组。

结论

幼年SD大鼠牙齿缺失会减少海马中锥体神经元的数量，抑制 、 和 的表达，并最终导致认知功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/d1eb70ffc904/fnins-16-839622-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/391e05959008/fnins-16-839622-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/307568a0f795/fnins-16-839622-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/1022b8c06c7a/fnins-16-839622-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/6dc5af8640a9/fnins-16-839622-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/d1eb70ffc904/fnins-16-839622-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/391e05959008/fnins-16-839622-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/307568a0f795/fnins-16-839622-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/1022b8c06c7a/fnins-16-839622-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/6dc5af8640a9/fnins-16-839622-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2770/9095951/d1eb70ffc904/fnins-16-839622-g005.jpg

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