Surolia Ranu, Antony Veena B
Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Front Cell Dev Biol. 2022 Apr 28;10:872759. doi: 10.3389/fcell.2022.872759. eCollection 2022.
Vimentin intermediate filaments, a type III intermediate filament, are among the most widely studied IFs and are found abundantly in mesenchymal cells. Vimentin intermediate filaments localize primarily in the cytoplasm but can also be found on the cell surface and extracellular space. The cytoplasmic vimentin is well-recognized for its role in providing mechanical strength and regulating cell migration, adhesion, and division. The post-translationally modified forms of Vimentin intermediate filaments have several implications in host-pathogen interactions, cancers, and non-malignant lung diseases. This review will analyze the role of vimentin beyond just the epithelial to mesenchymal transition (EMT) marker highlighting its role as a regulator of host-pathogen interactions and signaling pathways for the pathophysiology of various lung diseases. In addition, we will also examine the clinically relevant anti-vimentin compounds and antibodies that could potentially interfere with the pathogenic role of Vimentin intermediate filaments in lung disease.
波形蛋白中间丝属于III型中间丝，是研究最为广泛的中间丝之一，在间充质细胞中大量存在。波形蛋白中间丝主要定位于细胞质，但也可在细胞表面和细胞外空间发现。细胞质中的波形蛋白因其在提供机械强度以及调节细胞迁移、黏附和分裂方面的作用而广为人知。波形蛋白中间丝的翻译后修饰形式在宿主-病原体相互作用、癌症和非恶性肺部疾病中具有多种影响。本综述将分析波形蛋白不仅仅作为上皮-间质转化（EMT）标志物的作用，突出其作为宿主-病原体相互作用调节剂以及各种肺部疾病病理生理学信号通路的作用。此外，我们还将研究可能干扰波形蛋白中间丝在肺部疾病中致病作用的临床相关抗波形蛋白化合物和抗体。
