Kartsoli Sofia, Vrakas Spyridon, Kalomoiris Dimitrios, Manoloudaki Kassiani, Xourgias Vasileios
Tzaneio General Hospital of Piraeus, Department of Gastroenterology, Piraeus, Greece.
Tzaneio General Hospital of Piraeus, 3rd Department of Internal Medicine, Piraeus, Greece.
Autops Case Rep. 2022 Apr 28;12:e2021378. doi: 10.4322/acr.2021.378. eCollection 2022.
Although severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) affects mainly the respiratory system, the gastrointestinal tract is also considered a site of viral activity. We hereby present the case of a 74-year-old male patient with the diagnosis of new-onset ulcerative colitis. One month earlier, the patient presented fever, running nose, and diarrhea and was tested positive for SARS-CoV-2. Studies with COVID-19 patients revealed significant changes in gut microbiota composition and alterations in immune responses that could lead to chronic inflammation and manifestations of inflammatory bowel disease. We review additional cases of ulcerative colitis presented after SARS-CoV-2 infection and summarize the possible mechanisms that underlie the gastrointestinal abnormalities in COVID-19 patients.
尽管严重急性呼吸综合征冠状病毒2（SARS-CoV-2）主要影响呼吸系统，但胃肠道也被认为是病毒活动的场所。我们在此报告一例74岁男性患者，诊断为新发溃疡性结肠炎。一个月前，该患者出现发热、流鼻涕和腹泻，SARS-CoV-2检测呈阳性。对新冠肺炎患者的研究显示，肠道微生物群组成发生了显著变化，免疫反应也发生了改变，这可能导致慢性炎症和炎症性肠病的表现。我们回顾了SARS-CoV-2感染后出现的溃疡性结肠炎的其他病例，并总结了新冠肺炎患者胃肠道异常的潜在机制。
