The Role of RNA Methyltransferase in Normal and Malignant Hematopoiesis.

mA modification is the most common modification in eukaryotes. , as a core methyltransferase of mA modification, plays a vital role in normal and malignant hematopoiesis. Recent studies have shown that is required for normal and symmetric differentiation of hematopoietic stem/progenitor cells (HSPCs). Moreover, strongly impacts the process and development of hematological neoplasms, including the differentiation, apoptosis, proliferation, chemoresistance, and risk of tumors. Novel inhibitors of have been identified and studied in acute myeloid leukemia (AML) cells. STM2457, a selective inhibitor of , has been identified to block proliferation and promote differentiation and apoptosis of AML cells without impacting normal hematopoiesis. Therefore, in our present review, we focus on the structure of , the role of in both normal and malignant hematopoiesis, and the potential of for treating hematological neoplasms.