Beijing University of Chinese Medicine, China.
Chongqing Traditional Chinese Medicine Hospital, China.
Clin Nurs Res. 2022 Jul;31(6):1189-1198. doi: 10.1177/10547738221096550. Epub 2022 May 16.
To investigate adherence to immunosuppressive medication (IM) in kidney transplant recipients (KTRs) and analyze the associated factors using the Theory of Planned Behavior (TPB). Data were collected at Time1 (T1) and 3 months later (T2). T1: the elements of the TPB, past behavior, beliefs about medicines, perceived social support were measured. T2: IM adherence was measured. Structural equation modeling was applied to analyze the associated factors of medication adherence. A total of 246 KTRs were included. The average IM adherence score of KTRs' was 4.86 ( = 1.63). Of the recipients, 39.43% had one aspect of non-adherence to IM. The model could explain 28.7% of the variance in adherence to IM ( = .287, = .006). TPB is a useful tool for understanding adherence to IM in KTRs. Caregivers can provide effective interventions during follow-up, which should focus on improving medication beliefs as well as provision of other external support especially from outside.
采用计划行为理论（TPB）调查肾移植受者（KTR）的免疫抑制药物（IM）依从性，并分析相关影响因素。
本研究于 T1（基线）和 3 个月后（T2）收集数据。T1 时评估 TPB 的各个组成部分、既往行为、对药物的信念和感知社会支持；T2 时评估 IM 依从性。采用结构方程模型分析影响 IM 依从性的相关因素。
共纳入 246 例 KTR。KTRs 的 IM 平均依从性评分为 4.86（ = 1.63）。其中 39.43%的受者存在一个方面的 IM 不依从。该模型可以解释 IM 依从性 28.7%的方差（ = .287， = .006）。
TPB 是理解 KTR 对 IM 依从性的有用工具。护理人员在随访期间可以提供有效的干预措施，应重点改善对药物的信念，并提供其他外部支持，尤其是来自外部的支持。
