Tianjin Medical University General Hospital, Tianjin, China.
Integr Cancer Ther. 2022 Jan-Dec;21:15347354221096080. doi: 10.1177/15347354221096080.
Circadian genes regulate several physiological functions such as circadian rhythm and metabolism and participate in the cytogenesis and progression of various malignancies. The abnormal expression of these genes in non-small cell lung cancer (NSCLC) is closely related to the clinicopathological features of NSCLC and may promote or inhibit NSCLC progression. Circadian rhythm disorders and clock gene abnormalities may increase the risk of lung cancer in some populations. We collected 15 circadian genes in NSCLC, namely , and , and determined their relationships with the clinicopathological features of patients and the potential mechanisms promoting or inhibiting NSCLC progression. We also summarized the studies on circadian rhythm disorders and circadian genes associated with lung cancer risk. The present study aimed to provide theoretical support for the future exploration of new therapeutic targets and for the primary prevention of NSCLC from the perspective of circadian genes. Interpretation of circadian rhythms in lung cancer could guide further lung cancer mechanism research and drug development that could lead to more effective treatments and improve patient outcomes.
生物钟基因调节多种生理功能，如昼夜节律和代谢，并参与各种恶性肿瘤的细胞发生和进展。这些基因在非小细胞肺癌（NSCLC）中的异常表达与 NSCLC 的临床病理特征密切相关，可能促进或抑制 NSCLC 的进展。昼夜节律紊乱和时钟基因异常可能会增加某些人群患肺癌的风险。我们收集了 NSCLC 中的 15 个生物钟基因，即 、 和 ，并确定了它们与患者临床病理特征的关系及其促进或抑制 NSCLC 进展的潜在机制。我们还总结了生物钟节律紊乱与肺癌风险相关的基因研究。本研究旨在从生物钟基因的角度为未来探索新的治疗靶点和 NSCLC 的一级预防提供理论支持。对肺癌中昼夜节律的解读可以指导进一步的肺癌机制研究和药物开发，从而实现更有效的治疗并改善患者的预后。
