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限时喂养会影响肺癌小鼠的粪便微生物组代谢组及其昼夜波动。

Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice.

机构信息

Department of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University, Chongqing 400016, PR China; Center for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing 400016, PR China.

Department of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University, Chongqing 400016, PR China; Center for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing 400016, PR China.

出版信息

Neoplasia. 2023 Nov;45:100943. doi: 10.1016/j.neo.2023.100943. Epub 2023 Oct 16.


DOI:10.1016/j.neo.2023.100943
PMID:37852131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10590998/
Abstract

The homeostasis of the gut microbiota and circadian rhythm is critical to host health, and both are inextricably intertwined with lung cancer. Although time-restricted feeding (TRF) can maintain circadian synchronization and improve metabolic disorders, the effects of TRF on the fecal microbiome, metabolome and their diurnal oscillations in lung cancer have not been discussed. We performed 16S rRNA sequencing and untargeted metabonomic sequencing of the feces prepared from models of tumor-bearing BALB/c nude mice and urethane-induced lung cancer. We demonstrated for the first time that TRF significantly delayed the growth of lung tumors. Moreover, TRF altered the abundances of the fecal microbiome, metabolome and circadian clocks, as well as their rhythmicity, in lung cancer models of tumor-bearing BALB/c nude mice and/or urethane-induced lung cancer C57BL/6J mice. The results of fecal microbiota transplantation proved that the antitumor effects of TRF occur by regulating the fecal microbiota. Notably, Lactobacillus and Bacillus were increased upon TRF and were correlated with most differential metabolites. Pathway enrichment analysis of metabolites revealed that TRF mainly affected immune and inflammatory processes, which might further explain how TRF exerted its anticancer benefits. These findings underscore the possibility that the fecal microbiome/metabolome regulates lung cancer following a TRF paradigm.

摘要

肠道微生物组和昼夜节律的动态平衡对宿主健康至关重要,两者与肺癌都有着千丝万缕的联系。限时喂养(TRF)可以维持昼夜同步并改善代谢紊乱,但 TRF 对肺癌粪便微生物组、代谢组及其昼夜波动的影响尚未得到讨论。我们对荷瘤 BALB/c 裸鼠和尿烷诱导的肺癌模型的粪便进行了 16S rRNA 测序和非靶向代谢组学测序。我们首次证明,TRF 显著延缓了肺癌肿瘤的生长。此外,TRF 改变了荷瘤 BALB/c 裸鼠和/或尿烷诱导的 C57BL/6J 肺癌模型中粪便微生物组、代谢组和昼夜节律及其节律性。粪便微生物群移植的结果证明,TRF 通过调节粪便微生物群发挥抗肿瘤作用。值得注意的是,TRF 增加了乳杆菌和芽孢杆菌的数量,并且与大多数差异代谢物相关。代谢物的途径富集分析表明,TRF 主要影响免疫和炎症过程,这可能进一步解释了 TRF 发挥抗癌益处的机制。这些发现强调了粪便微生物组/代谢组可能通过 TRF 范式调节肺癌的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/0eecfabcb410/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/6c5515d35513/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/52f92920375f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/c73f74162a41/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/3f42dd268b02/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/88e66e2a7cde/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/0eecfabcb410/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/6c5515d35513/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/52f92920375f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/c73f74162a41/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/3f42dd268b02/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/88e66e2a7cde/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef63/10590998/0eecfabcb410/gr6.jpg

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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
Night eating in timing, frequency, and food quality and risks of all-cause, cancer, and diabetes mortality: findings from national health and nutrition examination survey.

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本文引用的文献

[1]
Live or Heat-Killed Aerosolization Decreases Adenomatous Lung Cancer Development in a Mouse Carcinogen-Induced Tumor Model.

Int J Mol Sci. 2022-10-22

[2]
Reducing light exposure enhances the circadian rhythm of the biological clock through interactions with the gut microbiota.

Sci Total Environ. 2023-2-1

[3]
A Combination of Two Probiotics, and , Inhibits Colon Cancer Development: An In Vitro Study.

Microorganisms. 2022-8-23

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Semin Cancer Biol. 2022-11

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Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome.

Cell Rep. 2022-7-5

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Int J Mol Sci. 2022-5-30

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Integr Cancer Ther. 2022

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Single-cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug-resistance in lung adenocarcinoma.

J Pineal Res. 2022-8

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Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag.

Nutrients. 2021-10-28

[10]
and in gut microbiota lessened in chronic liver diseases and hepatocellular carcinoma patients: a pilot study.

Bioengineered. 2021-12

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