Champalimaud Research and Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.
Department of Psychiatry and Mental Health, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
Brain Struct Funct. 2022 Dec;227(9):3121-3127. doi: 10.1007/s00429-022-02508-8. Epub 2022 May 16.
Lesion network mapping is a neuroimaging technique that explores the network of regions functionally connected to lesions causing a common syndrome. The technique uses resting state functional connectivity from large databases of healthy individuals, i.e., connectomes, and has allowed for important insight into the potential network mechanisms underlying several neuropsychiatric disorders. However, concerns regarding reproducibility have arisen, that may be due to the use of different connectomes, with variable MRI acquisition parameters and preprocessing methods. Here, we tested the impact of using different connectomes on the results of lesion network mapping for mania. We found results were reliable and consistent independent of the connectome used.
病灶网络映射是一种神经影像学技术，用于探索与导致常见综合征的病灶功能连接的区域网络。该技术使用来自健康个体的大型数据库的静息状态功能连接，即连接组学，这为理解几种神经精神障碍的潜在网络机制提供了重要的见解。然而，人们对可重复性的担忧已经出现，这可能是由于使用了不同的连接组学，具有不同的 MRI 采集参数和预处理方法。在这里，我们测试了使用不同的连接组学对躁狂症病灶网络映射结果的影响。我们发现，无论使用哪个连接组学，结果都是可靠且一致的。
