Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
CNS Neurosci Ther. 2023 Nov;29(11):3507-3517. doi: 10.1111/cns.14284. Epub 2023 Jun 12.
To detect functional connectomes of akinetic-rigid (AR) and tremor and compare their connection pattern.
Resting-state functional MRI data of 78 drug-naïve PD patients were enrolled to construct connectomes of AR and tremor via connectome-based predictive modeling (CPM). The connectomes were further validated with 17 drug-naïve patients to verify their replication.
The connectomes related to AR and tremor were identified via CPM method and successfully validated in the independent set. Additional regional-based CPM demonstrated neither AR nor tremor could be simplified to functional changes within a single brain region. Computational lesion version of CPM revealed that parietal lobe and limbic system were the most important regions among AR-related connectome, and motor strip and cerebellum were the most important regions among tremor-related connectome. Comparing two connectomes found that the patterns of connection between them were largely distinct, with only four overlapped connections identified.
AR and tremor were found to be associated with functional changes in multiple brain regions. Distinct connection patterns of AR-related and tremor-related connectomes suggest different neural mechanisms underlying the two symptoms.
检测无动性震颤僵硬（AR）和震颤的功能连接组，并比较它们的连接模式。
纳入 78 例未经药物治疗的 PD 患者的静息态功能 MRI 数据，通过基于连接组的预测建模（CPM）构建 AR 和震颤的连接组。进一步使用 17 例未经药物治疗的患者对连接组进行验证，以验证其可重复性。
通过 CPM 方法确定了与 AR 和震颤相关的连接组，并在独立数据集上成功验证。额外的基于区域的 CPM 表明，AR 和震颤都不能简化为单个脑区的功能变化。CPM 的计算损伤版本表明，顶叶和边缘系统是 AR 相关连接组中最重要的区域，而运动带和小脑是震颤相关连接组中最重要的区域。比较两个连接组发现，它们之间的连接模式存在很大的差异，仅确定了四个重叠的连接。
发现 AR 和震颤与多个脑区的功能变化有关。AR 相关和震颤相关连接组的不同连接模式表明，这两种症状的神经机制不同。
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