高密度脂蛋白与脂代谢。
HDL and Lipid Metabolism.
机构信息
The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, China.
Fujian Key Laboratory of Vascular Aging, Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
出版信息
Adv Exp Med Biol. 2022;1377:49-61. doi: 10.1007/978-981-19-1592-5_4.
Mediating reverse cholesterol transport (RCT) is the most classic function of HDL. HDL and HDL-C participate in the entire process of RCT, including cholesterol removal from cells, cholesterol transport in circulation, and cholesterol excretion. As cholesterol is a component of lipid rafts and lipid droplets in cells, HDL and RCT can influence cell activity. HDL has also been shown to be related to the metabolism of some other biological lipids, such as S1P and ox-PL. Here we will introduce in detail the molecular mechanism of HDL participation in RCT and its significance.
介导胆固醇逆转运（RCT）是 HDL 最经典的功能。HDL 和 HDL-C 参与 RCT 的整个过程，包括细胞内胆固醇的清除、循环中胆固醇的转运和胆固醇的排泄。由于胆固醇是细胞内脂筏和脂滴的组成部分，因此 HDL 和 RCT 可以影响细胞活性。此外，HDL 还与一些其他生物脂质（如 S1P 和 ox-PL）的代谢有关。本文将详细介绍 HDL 参与 RCT 的分子机制及其意义。
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