Department of Gynae & Obs. Ayub Teaching Hospital Abbottabad, Pakistan.
Pak Emirates Military Hospital Rawalpindi, Pakistan.
J Ayub Med Coll Abbottabad. 2022 Apr-Jun;34(2):269-272. doi: 10.55519/JAMC-02-8478.
Pregnancy poses some stress on normal homeostasis of the human body and brings changes in the body which predisposes the individual towards various pathological conditions as well.
Objective of the study was to determine the magnetic resonance imaging (MRI) changes and clinical symptoms associated with these changes among patients of eclampsia and preeclampsia managed at tertiary care unit. It was a cross-sectional study, conducted at Gynaecology and obstetrics department Pak Emirates Military Hospital (PEMH) Rawalpindi. January to June 2019.
A total of 80 pregnant women who were diagnosed by consultant obstetrician for eclampsia or pre-eclampsia were included in the study. All the patients underwent Plain MRI brain including TIWI, T2WI, FLAIR, DWI, ADC, GRE and SWI sequences at radiology department of PEMH RWP. Positive MRI findings were defined as presence of cerebral oedema, infarction, cerebral venous sinus thrombosis and cerebral haemorrhage. Headache, seizures, altered mental status and visual problems were correlated with MRI changes among the target population.
Out of 80 pregnant women with eclampsia or preeclampsia, 49 (61.2%) had no changes on MRI while 31 (38.8%) had significant changes on MRI. Cerebral oedema 12 (15%) was the most common MRI finding followed by cerebral haemorrhage 8 (10%). Mean age of participants was 36.33±2.238 years. With Pearson chi-square analysis, it was found that presence of seizures and altered mental state had statistically significant relationship with presence of MRI findings among the target population.
MRI changes were a common finding among the patients of eclampsia or pre-eclampsia. Cerebral oedema was the commonest finding in our study. Patients with serious clinical symptoms like seizures and altered mental state had more chances of having MRI changes as compared to patients without the serious clinical symptoms.
怀孕会对人体的正常内稳态造成一定压力，并使身体发生变化，从而使个体容易患上各种病理情况。
本研究旨在确定在三级保健单位接受治疗的子痫和先兆子痫患者的磁共振成像（MRI）变化和与这些变化相关的临床症状。这是一项在拉瓦尔品第的巴基斯坦军事医院妇产科进行的横断面研究。2019 年 1 月至 6 月。
共纳入 80 名被顾问妇产科医生诊断为子痫或先兆子痫的孕妇。所有患者均在拉瓦尔品第巴基斯坦军事医院放射科进行了包括 TIWI、T2WI、FLAIR、DWI、ADC、GRE 和 SWI 序列的平扫 MRI 脑检查。阳性 MRI 发现定义为存在脑水肿、梗死、脑静脉窦血栓形成和脑出血。头痛、癫痫发作、意识状态改变和视觉问题与目标人群的 MRI 变化相关。
在 80 名患有子痫或先兆子痫的孕妇中，49 名（61.2%）MRI 无变化，31 名（38.8%）MRI 有明显变化。脑水肿 12 例（15%）是最常见的 MRI 发现，其次是脑出血 8 例（10%）。参与者的平均年龄为 36.33±2.238 岁。通过皮尔逊卡方分析，发现癫痫发作和意识状态改变与目标人群的 MRI 发现之间存在统计学显著关系。
MRI 变化是子痫或先兆子痫患者的常见发现。在我们的研究中，脑水肿是最常见的发现。与没有严重临床症状的患者相比，有严重临床症状（如癫痫发作和意识状态改变）的患者更有可能出现 MRI 变化。
