Ye Zichen, Fan Yiyang, Zhu Tianbao, Cao Dongxu, Hu Xinyan, Xiang Sijin, Li Jingchao, Guo Zhide, Chen Xiaolan, Tan Kai, Zheng Nanfeng
State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
ACS Appl Mater Interfaces. 2022 May 16. doi: 10.1021/acsami.2c03952.
Noble metal nanozymes have shown great promise in biomedicine; however, developing novel and high-performance noble metal nanozymes is still highly pressing and challenging. Herein, we, for the first time, prepared two-dimensional (2D) Pd@Ir bimetal nanosheets (NSs) with well-defined size and composition by a facile seed-mediated growth strategy. Enzyme-mimicked investigations find that the Pd@Ir NSs possess oxidase (OXD)-, peroxidase (POD)-, and catalase (CAT)-like multienzyme-mimetic activities. Especially, they exhibited much higher OXD- and POD-like activities than individual Pd NSs and Ir nanoparticles (NPs). The density functional theory (DFT) calculations reveal that the adsorption energy of O on Pd@Ir NSs is lower than that on the pure Pd NSs, which is more favorable for the conversion of O molecules from the triplet state (O) into the singlet state (O). Finally, based on the outstanding nanozyme activities to yield highly active singlet oxygen (O) and hydroxyl radicals (•OH) as well as excellent biosafety, the as-prepared Pd@Ir NSs were applied to treat bacteria-infected wounds, and satisfactory therapeutic outcomes were achieved. We believe that the highly efficient 2D Pd@Ir nanozyme will be an effective therapeutic reagent for various biomedical applications.
贵金属纳米酶在生物医学领域已展现出巨大潜力；然而，开发新型高性能贵金属纳米酶仍然极为迫切且具有挑战性。在此，我们首次通过简便的种子介导生长策略制备了尺寸和组成明确的二维（2D）Pd@Ir双金属纳米片（NSs）。酶模拟研究发现，Pd@Ir NSs具有类氧化酶（OXD）、类过氧化物酶（POD）和类过氧化氢酶（CAT）的多酶模拟活性。特别是，它们表现出比单个Pd NSs和Ir纳米颗粒（NPs）更高的类OXD和类POD活性。密度泛函理论（DFT）计算表明，O在Pd@Ir NSs上的吸附能低于在纯Pd NSs上的吸附能，这更有利于O分子从三重态（O）转化为单重态（O）。最后，基于产生高活性单线态氧（O）和羟基自由基（•OH）的出色纳米酶活性以及优异的生物安全性，所制备的Pd@Ir NSs被应用于治疗细菌感染伤口，并取得了令人满意的治疗效果。我们相信，这种高效的二维Pd@Ir纳米酶将成为用于各种生物医学应用的有效治疗试剂。
