Buoncristiani U, Ragaiolo M, Petrucci V, Bruni F, Pala E, Damiani C, Brugnano R
Int J Artif Organs. 1986 Dec;9 Suppl 3:9-14.
The presence of acetate in the dialysate appears to be superfluous in the new depurative technique indicated as biofiltration, which consists in a standard hemodialysis with high ultrafiltration combined with the reinfusion of 3-4 1/2 liters of solution containing bicarbonate. The presence of acetate could in fact be contraindicated by a number of potential side effects, metabolic, cardiovascular and biological. Hence, starting from the consideration that in standard biofiltration a buffer is already infused directly as bicarbonate, we tried to overcome the potential hazards of the acetate-containing bath simply by using a dialysate without acetate and by increasing the concentration of bicarbonate in the reinfusate. A cumulative clinical experience of 20 months in 4 patients proved the feasibility and safety of the technique and suggests further advantages over standard biofiltration (better control of acid-base equilibrium, better cardiovascular stability.
在一种名为生物滤过的新型净化技术中，透析液中存在醋酸盐似乎是多余的。这种技术是在标准血液透析基础上进行高超滤，并回输3至4.5升含碳酸氢盐的溶液。事实上，醋酸盐的存在可能因多种潜在副作用而不宜使用，这些副作用涉及代谢、心血管和生物学方面。因此，基于在标准生物滤过中已直接输入碳酸氢盐作为缓冲剂这一考虑，我们试图通过使用不含醋酸盐的透析液并提高回输液中碳酸氢盐的浓度，来克服含醋酸盐透析液的潜在危害。4名患者20个月的累积临床经验证明了该技术的可行性和安全性，并表明其相对于标准生物滤过还有其他优势（能更好地控制酸碱平衡，心血管稳定性更佳）。
