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西班牙克罗恩病和溃疡性结肠炎小组关于炎症性肠病患者重要性、筛查和疫苗接种的建议。

Recommendations of the Spanish Group on Crohn's Disease and Ulcerative Colitis on the importance, screening and vaccination in inflammatory bowel disease patients.

机构信息

Servicio de Gastroenterología, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, España; Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, A Coruña, España.

Servicio de Gastroenterología, Consorci Sanitari de Terrassa (CST), Terrassa, Barcelona, España.

出版信息

Gastroenterol Hepatol. 2022 Dec;45(10):805-818. doi: 10.1016/j.gastrohep.2022.03.012. Epub 2022 May 14.

Abstract

Patients with inflammatory bowel disease (IBD) may require different immunosuppressive treatments throughout their illness. It is essential to assess the immunization status of patients at diagnosis or, if this is not possible, at least before the beginning of immunosuppressive therapy and, subsequently, administering the appropriate vaccines. Therefore, the aim of this work is to establish clear and concise recommendations on vaccination in patients with IBD in the different settings of our clinical practice including vaccination in children, during pregnancy, breastfeeding or on trips. This consensus document emphasises the differences between inactivated and attenuated vaccines and the different degrees of immunosuppression and correlates them with the administration of both mandatory and optional vaccines recommended to our patients with IBD. Finally, as a summary, 17 recommendations are established based on the available scientific evidence and expert opinion. A multidisciplinary team with extensive experience in IBD and vaccination, made up of specialists in gastroenterology, paediatrics, nursing and pharmacy, has participated in the preparation of these recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis.

摘要

患有炎症性肠病(IBD)的患者在整个疾病过程中可能需要不同的免疫抑制治疗。评估患者的免疫接种状态至关重要,在诊断时(如果无法做到,则至少在开始免疫抑制治疗之前),并随后接种适当的疫苗。因此,本工作旨在根据我们临床实践中的不同情况(包括儿童、妊娠、哺乳或旅行期间的疫苗接种),制定关于 IBD 患者接种疫苗的明确和简洁的建议。本共识文件强调了灭活疫苗和减毒疫苗之间的差异,以及不同程度的免疫抑制,并将其与推荐给 IBD 患者的强制性和非强制性疫苗的接种相联系。最后,作为总结,根据现有科学证据和专家意见制定了 17 项建议。一个在 IBD 和疫苗接种方面拥有丰富经验的多学科团队,由胃肠病学、儿科学、护理和药学专家组成,参与了这些由西班牙克罗恩病和溃疡性结肠炎工作组制定的建议。

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