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西班牙克罗恩病和溃疡性结肠炎研究组(GETECCU)、西班牙肥胖学会(SEEDO)、西班牙外科学会(AEC)和西班牙消化内镜学会(SEED)关于炎症性肠病严重肥胖患者管理的建议。

Recommendations on the management of severe obesity in patients with inflammatory bowel disease of the Spanish Group on Crohn's Disease and Ulcerative Colitis (GETECCU), Spanish Society of Obesity (SEEDO), Spanish Association of Surgery (AEC) and Spanish Society of Digestive Endoscopy (SEED).

机构信息

Servicio de Aparato Digestivo, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD); Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, España.

Departament de Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Barcelona, España; Servicio de Endocrinología y Nutrición, Hospital Universitari Vall d'Hebron, Barcelona, España; Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, España.

出版信息

Gastroenterol Hepatol. 2024 Oct;47(8):906-923. doi: 10.1016/j.gastrohep.2023.12.008. Epub 2024 Jan 28.

Abstract

Obesity is a multifactorial, chronic, progressive and recurrent disease considered a public health issue worldwide and an important determinant of disability and death. In Spain, its current prevalence in the adult population is about 24% and an estimated prevalence in 2035 of 37%. Obesity increases the probability of several diseases linked to higher mortality such as diabetes, cardiovascular disease, hyperlipidemia, arterial hypertension, non-alcoholic fatty liver disease, several types of cancer, or obstructive sleep apnea. On the other hand, although the incidence of inflammatory bowel disease (IBD) is stabilizing in Western countries, its prevalence already exceeds 0.3%. Paralleling to general population, the current prevalence of obesity in adult patients with IBD is estimated at 15-40%. Obesity in patients with IBD could entail, in addition to its already known impact on disability and mortality, a worse evolution of the IBD itself and a worse response to treatments. The aim of this document, performed in collaboration by four scientific societies involved in the clinical care of severe obesity and IBD, is to establish clear and concise recommendations on the therapeutic possibilities of severe or typeIII obesity in patients with IBD. The document establishes general recommendations on dietary, pharmacological, endoscopic, and surgical treatment of severe obesity in patients with IBD, as well as pre- and post-treatment evaluation.

摘要

肥胖是一种多因素、慢性、进行性和复发性疾病,被认为是全球范围内的公共卫生问题,也是残疾和死亡的一个重要决定因素。在西班牙,成年人肥胖的患病率约为 24%,预计到 2035 年将达到 37%。肥胖增加了多种与更高死亡率相关的疾病的可能性,如糖尿病、心血管疾病、高脂血症、动脉高血压、非酒精性脂肪性肝病、多种类型的癌症或阻塞性睡眠呼吸暂停。另一方面,尽管炎症性肠病(IBD)在西方国家的发病率趋于稳定,但它的患病率已经超过 0.3%。与普通人群一样,IBD 成年患者的肥胖患病率估计在 15-40%之间。IBD 患者的肥胖除了已经知道的对残疾和死亡率的影响外,还可能导致 IBD 本身的恶化和对治疗的反应更差。本文件由四个参与严重肥胖和 IBD 临床护理的科学协会合作编写,旨在为 IBD 患者严重或 III 型肥胖的治疗可能性制定明确和简洁的建议。本文件为 IBD 患者严重肥胖的饮食、药物、内镜和手术治疗以及治疗前后评估制定了一般建议。

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