自噬在食管癌的发生、发展、TME 修饰、诊断和治疗中的作用。
The role of autophagy in initiation, progression, TME modification, diagnosis, and treatment of esophageal cancers.
机构信息
Department of Radiation Oncology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi 710018, China; Laboratory of Cellular and Molecular Radiation Oncology, The Affiliated Taizhou Hospital, Wenzhou Medical University, Taizhou 317000, Zhejiang, China; Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Taizhou, China.
Laboratory of Cellular and Molecular Radiation Oncology, The Affiliated Taizhou Hospital, Wenzhou Medical University, Taizhou 317000, Zhejiang, China; Department of Radiation Oncology, The Affiliated Taizhou Hospital, Wenzhou Medical University, Taizhou, China.
出版信息
Crit Rev Oncol Hematol. 2022 Jul;175:103702. doi: 10.1016/j.critrevonc.2022.103702. Epub 2022 May 14.
Autophagy is a highly conserved metabolic process with a cytoprotective function. Autophagy is involved in cancer, infection, immunity, and inflammation and may be a potential therapeutic target. Increasing evidence has revealed that autophagy has primary implications for esophageal cancer, including its initiation, progression, tumor microenvironment (TME) modification, diagnosis, and treatment. Notably, autophagy displayed excellent application potential in radiotherapy combined with immunotherapy. Radiotherapy combined with immunotherapy is a new potential therapeutic strategy for cancers, including esophageal cancer. Autophagy modulators can work as adjuvant enhancers in radiotherapy or immunotherapy of cancers. This review highlights the most recent data related to the role of autophagy regulation in esophageal cancer.
自噬是一种具有细胞保护功能的高度保守的代谢过程。自噬参与癌症、感染、免疫和炎症，可能是一个潜在的治疗靶点。越来越多的证据表明，自噬对食管癌具有重要意义，包括其发生、进展、肿瘤微环境（TME）修饰、诊断和治疗。值得注意的是，自噬在放化疗联合免疫治疗中显示出了极好的应用潜力。放化疗联合免疫治疗是癌症（包括食管癌）的一种新的潜在治疗策略。自噬调节剂可作为癌症放化疗或免疫治疗的辅助增强剂。本综述重点介绍了与自噬调控在食管癌中的作用相关的最新数据。
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