Yang Tiantian, Zhang Yang, Chen Junhang, Sun Longhao
Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Front Med (Lausanne). 2023 Feb 6;10:1125692. doi: 10.3389/fmed.2023.1125692. eCollection 2023.
Autophagy is a conserved process for self-degradation and provides cells with a rescue mechanism to respond to circumstances such as stress and starvation. The role of autophagy in cancer is extremely complex and often paradoxical. Most of the related published studies on tumors are always focused on cancer cells. However, present studies gradually noticed the significance of autophagy in the tumor microenvironment. These studies demonstrate that autophagy and immunity work synergistically to affect tumor progression, indicating that autophagy could become a potential target for cancer immunotherapy. Therefore, it is crucial to clarify the correlation between autophagy and various tumor-infiltrating immune cells in the tumor microenvironment. The context-dependent role of autophagy is critical in the design of therapeutic strategies for cancer.
自噬是一种保守的自我降解过程，为细胞提供了一种应对压力和饥饿等情况的挽救机制。自噬在癌症中的作用极其复杂，且往往自相矛盾。大多数已发表的关于肿瘤的相关研究总是聚焦于癌细胞。然而，目前的研究逐渐注意到自噬在肿瘤微环境中的重要性。这些研究表明，自噬与免疫协同作用以影响肿瘤进展，这表明自噬可能成为癌症免疫治疗的一个潜在靶点。因此，阐明肿瘤微环境中自噬与各种肿瘤浸润免疫细胞之间的相关性至关重要。自噬的背景依赖性作用在癌症治疗策略的设计中至关重要。
