犬甲下色素性鳞状细胞癌。

Subungual Pigmented Squamous Cell Carcinoma in a Dog.

机构信息

Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.

Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.

出版信息

J Comp Pathol. 2022 Jun;194:50-53. doi: 10.1016/j.jcpa.2022.03.010. Epub 2022 Apr 27.

DOI:10.1016/j.jcpa.2022.03.010

PMID:35577459

Abstract

An 11-year-old spayed female Miniature Schnauzer dog was presented with loss of a claw caused by a nail bed mass. Histopathological evaluation revealed that the mass comprised neoplastic squamous cells with abundant cytoplasmic melanin pigment. Immunohistochemically, the neoplastic cells were positive for cytokeratin and negative for vimentin and ionized calcium-binding adaptor molecule 1, supporting a diagnosis of pigmented squamous cell carcinoma. To our knowledge, this is the first report of subungual pigmented squamous cell carcinoma in animals.

摘要

一只 11 岁已去势的雌性迷你雪纳瑞犬因爪床肿块而导致指甲缺失。组织病理学评估显示，肿块由富含细胞浆黑色素的肿瘤性鳞状细胞组成。免疫组织化学染色显示，肿瘤细胞角蛋白阳性，波形蛋白和钙结合蛋白 1 阴性，支持色素性鳞状细胞癌的诊断。据我们所知，这是首例动物发生的甲下色素性鳞状细胞癌的报告。