Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001, Santo André, SP 09210-580, Brazil.
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados, 5001, Santo André, SP 09210-580, Brazil; Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, Rua Sérgio Buarque de Holanda, 777 - Cidade Universitária, Campinas, SP 13083-859, Brazil.
Mater Sci Eng C Mater Biol Appl. 2022 Apr;135:112655. doi: 10.1016/j.msec.2022.112655. Epub 2022 Jan 10.
Magnetic bioactive glass-ceramics are biomaterials applied for magnetic hyperthermia in bone cancer treatment, thereby treating the bone tumor besides regenerating the damaged bone. However, combining high bioactivity and high saturation magnetization remains a challenge since the thermal treatment step employed to grow magnetic phases is also related to loss of bioactivity. Here, we propose a new nanocomposite made of superparamagnetic iron oxide nanoparticles (SPIONs) dispersed in a sol-gel-derived bioactive glass matrix, which does not need any thermal treatment for crystallization of magnetic phases. The scanning and transmission electron microscopies, X-ray diffraction, and dynamic light scattering results confirm that the SPIONs are actually embedded in a nanosized glass matrix, thus forming a nanocomposite. Magnetic and calorimetric characterizations evidence their proper behavior for hyperthermia applications, besides evidencing inter-magnetic nanoparticle interactions within the nanocomposite. Bioactivity and in vitro characterizations show that such nanocomposites exhibit apatite-forming properties similar to the highly bioactive parent glass, besides being osteoinductive. This methodology is a new alternative to produce magnetic bioactive materials to which the magnetic properties only rely on the quality of the SPIONs used in the synthesis. Thereby, these nanocomposites can be recognized as a new class of bioactive materials for applications in bone cancer treatment by hyperthermia.
磁性生物活性玻璃陶瓷是一种应用于骨癌磁热疗的生物材料，既能治疗骨肿瘤，又能再生受损骨骼。然而，由于用于生长磁性相的热疗步骤也与生物活性的丧失有关，因此结合高生物活性和高饱和磁化强度仍然是一个挑战。在这里，我们提出了一种由超顺磁性氧化铁纳米粒子（SPIONs）分散在溶胶-凝胶衍生的生物活性玻璃基质中的新型纳米复合材料，它不需要任何热疗来使磁性相结晶。扫描和透射电子显微镜、X 射线衍射和动态光散射结果证实，SPIONs 实际上嵌入在纳米尺寸的玻璃基质中，从而形成了纳米复合材料。磁性和量热特性证明了它们在热疗应用中的适当行为，同时也证明了纳米复合材料中磁性纳米粒子之间的相互作用。生物活性和体外特性表明，这种纳米复合材料具有类似于高生物活性母体玻璃的磷灰石形成特性，同时还具有成骨诱导性。这种方法是生产磁性生物活性材料的一种新方法，其磁性仅依赖于合成中使用的 SPIONs 的质量。因此，这些纳米复合材料可以被认为是一类新的生物活性材料，可用于骨癌的热疗治疗。
