Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, South Korea.
Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea.
Commun Biol. 2022 May 16;5(1):462. doi: 10.1038/s42003-022-03424-7.
Fractures and related complications are a common challenge in the field of skeletal tissue engineering. Vitamin D and calcium are the only broadly available medications for fracture healing, while zinc has been recognized as a nutritional supplement for healthy bones. Here, we aimed to use polaprezinc, an anti-ulcer drug and a chelate form of zinc and L-carnosine, as a supplement for fracture healing. Polaprezinc induced upregulation of osteogenesis-related genes and enhanced the osteogenic potential of human bone marrow-derived mesenchymal stem cells and osteoclast differentiation potential of mouse bone marrow-derived monocytes. In mouse experimental models with bone fractures, oral administration of polaprezinc accelerated fracture healing and maintained a high number of both osteoblasts and osteoclasts in the fracture areas. Collectively, polaprezinc promotes the fracture healing process efficiently by enhancing the activity of both osteoblasts and osteoclasts. Therefore, we suggest that drug repositioning of polaprezinc would be helpful for patients with fractures.
骨折及相关并发症是骨骼组织工程领域的常见挑战。维生素 D 和钙是唯一广泛用于骨折愈合的药物，而锌已被认为是健康骨骼的营养补充剂。在这里，我们旨在使用抗炎锌和 L-肉毒碱的螯合物——普拉曲沙作为骨折愈合的补充剂。普拉曲沙诱导骨生成相关基因的上调，并增强了人骨髓间充质干细胞的成骨潜能和小鼠骨髓来源单核细胞的破骨细胞分化潜能。在骨折的小鼠实验模型中，普拉曲沙的口服给药加速了骨折愈合，并维持了骨折部位较高数量的成骨细胞和破骨细胞。总的来说，普拉曲沙通过增强成骨细胞和破骨细胞的活性，有效地促进了骨折愈合过程。因此，我们建议将普拉曲沙重新定位为药物，这将对骨折患者有所帮助。
