Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, 71-210 Szczecin, Poland.
Department of Propedeutics of Internal Diseases and Arterial Hypertension, Pomeranian Medical University, 71-252 Szczecin, Poland.
Biomolecules. 2021 Feb 8;11(2):237. doi: 10.3390/biom11020237.
The aim of this study was to assess the associations of serum and bone zinc (Zn) and cuprum (Cu) with bone mineral density (BMD) and content (BMC), markers of bone turnover, and sex hormones. The study group comprised 144 men treated with total hip replacement due to hip osteoarthritis. We measured total, free, and bioavailable testosterone, estradiol, and sex-hormone-binding globulin (sex hormones), as well as parathyroid hormone, osteocalcin, carboxy terminal collagen crosslinks, and N-terminal propeptide of type I procollagen (markers of bone turnover). Total body BMD, BMC, total and visceral fat, and appendicular skeletal mass (ASM) were measured using dual-energy X-ray absorptiometry. ASM index, and total and visceral fat were positively correlated with BMD. Bone Zn correlated neither with sex hormones nor with bone turnover markers; however, it was positively associated both with BMD and with BMC, while bone Cu (as opposed to serum Cu) was not. In multiple regression, the ASM index, Zn/Cu ratio (in both the serum and the bone), and serum Cu concentration were significantly associated with BMD and BMC after adjustment for age and body mass index (BMI). Our results suggest that the Zn/Cu ratio in both the serum and the bone may exert a significant positive effect on total BMD and BMC.
本研究旨在评估血清和骨锌（Zn）和铜（Cu）与骨密度（BMD）和骨量（BMC）、骨转换标志物以及性激素之间的关系。研究对象为 144 名因髋骨关节炎接受全髋关节置换术的男性。我们测量了总睾酮、游离睾酮和生物可利用睾酮、雌二醇和性激素结合球蛋白（性激素），以及甲状旁腺激素、骨钙素、羧基末端胶原交联和 I 型前胶原 N 端肽（骨转换标志物）。使用双能 X 射线吸收法测量全身 BMD、BMC、全身和内脏脂肪以及四肢骨骼质量（ASM）。ASM 指数以及全身和内脏脂肪与 BMD 呈正相关。骨 Zn 与性激素和骨转换标志物均无相关性；然而，它与 BMD 和 BMC 呈正相关，而血清 Cu 则无相关性。在调整年龄和体重指数（BMI）后，多元回归分析显示，ASM 指数、血清和骨中的 Zn/Cu 比值以及血清 Cu 浓度与 BMD 和 BMC 显著相关。我们的结果表明，血清和骨中的 Zn/Cu 比值可能对总 BMD 和 BMC 产生显著的正向影响。
