Department of Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9th Jinsui Road, Tianhe District, Guangzhou, 510623, China.
Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou, China.
Sci Rep. 2022 May 16;12(1):8102. doi: 10.1038/s41598-022-12207-3.
The aim of this study was to examine the associations of sleep problems with asthma and allergic rhinitis among Chinese preschoolers. This cross-sectional survey was conducted in Guangzhou, China. Children aged 3-6 years were recruited from 32 kindergartens in 7 administrative districts. Asthma, allergic rhinitis and sleep problems were evaluated using a valid questionnaire. Binary logistic regression models were employed to estimate the odds ratios (OR) and 95% confidence intervals (CI) for the associations of asthma and allergic rhinitis with short sleep duration, late bedtime and frequent nocturnal awakening. We included 4876 preschool children in the current analysis. Of these, 182 (3.7%) diagnosed as asthma, and 511 (10.5%) diagnosed as allergic rhinitis. Frequent nocturnal awakening was associated with asthma and allergic rhinitis, with adjusted OR were 1.49 (95% CI 1.05-2.13) and 1.59 (95% CI 1.27-1.99), respectively. Subgroup analysis showed the OR for frequent nocturnal awakening with asthma was higher in girls (1.68; 95% CI 1.02-2.78) than in boys (1.35; 95% CI 0.81-2.24), but the OR for frequent nocturnal awakening with allergic rhinitis were similar in girls (1.73; 95% CI 1.15-2.30) and boys (1.57; 95% CI 1.17-2.12). No significant associations of short sleep duration and late bedtime with asthma or allergic rhinitis were identified. Our data suggested that frequent nocturnal awakening was associated with asthma and allergic rhinitis among preschoolers, and the association of frequent nocturnal awakening with asthma differed by gender. Further studies are warranted to address the causal relationship between nocturnal awakening and asthma and allergic rhinitis.
本研究旨在探讨中国学龄前儿童睡眠问题与哮喘和过敏性鼻炎的关系。这是一项在中国广州进行的横断面调查。研究从 7 个行政区的 32 所幼儿园招募了 3-6 岁的儿童。使用有效的问卷评估哮喘、过敏性鼻炎和睡眠问题。采用二元逻辑回归模型估计哮喘和过敏性鼻炎与睡眠持续时间短、晚睡和夜间频繁觉醒的关联的优势比（OR）和 95%置信区间（CI）。我们共纳入 4876 名学龄前儿童进行了本分析。其中，182 名（3.7%）被诊断为哮喘，511 名（10.5%）被诊断为过敏性鼻炎。频繁夜间觉醒与哮喘和过敏性鼻炎有关，调整后的 OR 分别为 1.49（95%CI 1.05-2.13）和 1.59（95%CI 1.27-1.99）。亚组分析显示，女孩频繁夜间觉醒与哮喘的 OR 高于男孩（1.68；95%CI 1.02-2.78），而女孩频繁夜间觉醒与过敏性鼻炎的 OR 与男孩相似（1.73；95%CI 1.15-2.30）和男孩（1.57；95%CI 1.17-2.12）。睡眠持续时间短和晚睡与哮喘或过敏性鼻炎之间无显著关联。我们的数据表明，频繁夜间觉醒与学龄前儿童哮喘和过敏性鼻炎有关，且频繁夜间觉醒与哮喘的关联因性别而异。需要进一步的研究来确定夜间觉醒与哮喘和过敏性鼻炎之间的因果关系。
