Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing, China; National Centre for International Research of Low-carbon and Green Buildings (Ministry of Science and Technology), Chongqing University, Chongqing, China.
Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing, China; National Centre for International Research of Low-carbon and Green Buildings (Ministry of Science and Technology), Chongqing University, Chongqing, China.
Environ Int. 2020 Jul;140:105752. doi: 10.1016/j.envint.2020.105752. Epub 2020 May 1.
Many studies have investigated the associations between household damp indicators, and allergies and respiratory diseases in childhood. However, the findings are rather inconsistent. In 2010, we conducted a cross-sectional study of preschoolers aged three-six years in three urban districts of Chongqing, China. In 2019, we repeated this cross-sectional study with preschoolers of the same ages and districts. Here, we selected data for 2935 and 2717 preschoolers who did not change residences since birth in the 2010 and 2019 studies, respectively. We investigated associations of household damp indicators with asthma, allergic rhinitis, pneumonia, eczema, wheeze, and rhinitis in childhood in the two studies. The proportions of residences with household damp indicators and the prevalence of the studied diseases (except for allergic rhinitis) were significantly lower in 2019 than in 2010. In the two-level (district-child) logistic regression analyses, household damp exposures that showed by different indicators were significantly associated with the increased odds of lifetime-ever asthma (range of adjusted odds ratio (AOR): 1.69-3.50 in 2019; 1.13-1.90 in 2010), allergic rhinitis (1.14-2.39; 0.67-1.61), pneumonia (1.09-1.64; 1.21-1.59), eczema (0.96-1.83; 0.99-1.56), wheeze (1.64-2.79; 1.18-1.91), rhinitis (1.43-2.71; 1.08-1.58), and current (in the past 12 months before the survey) eczema (0.46-2.08; 0.99-1.48), wheeze (0.97-2.86; 1.26-2.07) and rhinitis (1.34-2.25; 1.09-1.56) in most cases. The increased odds ratios (ORs) of most diseases had exposure-response relationships with the cumulative number (n) of household damp indicators in the current and early residences. Our results indicated household damp exposure could be a risk factor for childhood allergic and respiratory diseases, although the magnitudes of these effects could be different in different studies.
许多研究调查了家庭潮湿指标与儿童过敏和呼吸道疾病之间的关联。然而，这些发现相当不一致。2010 年，我们在中国三个城区对 3-6 岁的学龄前儿童进行了一项横断面研究。2019 年，我们在同一地区和年龄的学龄前儿童中重复了这项横断面研究。在这里，我们选择了 2010 年和 2019 年研究中自出生以来未搬家的 2935 名和 2717 名学龄前儿童的数据。我们调查了家庭潮湿指标与儿童期哮喘、过敏性鼻炎、肺炎、特应性皮炎、喘息和鼻炎的关联。与 2010 年相比，2019 年居住环境中存在家庭潮湿指标的比例和所研究疾病（过敏性鼻炎除外）的患病率明显降低。在两级（区-儿童）逻辑回归分析中，不同指标显示的家庭潮湿暴露与终生哮喘（调整后的比值比（AOR）范围：2019 年为 1.69-3.50；2010 年为 1.13-1.90）、过敏性鼻炎（1.14-2.39；0.67-1.61）、肺炎（1.09-1.64；1.21-1.59）、特应性皮炎（0.96-1.83；0.99-1.56）、喘息（1.64-2.79；1.18-1.91）、鼻炎（1.43-2.71；1.08-1.58）和当前（在调查前 12 个月内）特应性皮炎（0.46-2.08；0.99-1.48）、喘息（0.97-2.86；1.26-2.07）和鼻炎（1.34-2.25；1.09-1.56）的患病几率显著增加。在大多数情况下，大多数疾病的优势比（OR）与当前和早期居住环境中家庭潮湿指标的累积数量（n）之间存在暴露-反应关系。我们的研究结果表明，家庭潮湿暴露可能是儿童过敏和呼吸道疾病的一个危险因素，尽管这些影响的程度在不同的研究中可能不同。
