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理解黑种人与白种人乳腺癌死亡率差距的驱动因素:呼吁更有力的定义。

Understanding drivers of the Black:White breast cancer mortality gap: A call for more robust definitions.

机构信息

Department of Surgery, Division of Breast Surgery, City of Hope, Duarte, California.

Department of Surgery, City of Hope, Duarte, California.

出版信息

Cancer. 2022 Jul 15;128(14):2695-2697. doi: 10.1002/cncr.34243. Epub 2022 May 17.

DOI:10.1002/cncr.34243
PMID:35578909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9325488/
Abstract

Kim et al completed a pooled analysis of 8 National Surgical Adjuvant Breast and Bowel Project trials and highlight that, when compared with White patients, Black patients with estrogen receptor–positive (ER+) breast cancer have worse distant recurrence‐free survival, especially in the setting of neoadjuvant chemotherapy when pathologic complete response is not achieved. This editorial highlights that, to comprehend the drivers of this disparity, we must have more robust definitions of ER+ breast cancer and race.

摘要

金等人对 8 项美国国家癌症综合网络外科辅助乳腺与肠道项目试验进行了汇总分析,强调与白人患者相比,雌激素受体阳性(ER+)乳腺癌黑人患者的远处无复发生存更差,尤其是在未达到病理完全缓解的新辅助化疗环境下。这篇社论强调,为了理解这种差异的驱动因素,我们必须对 ER+乳腺癌和种族有更严格的定义。

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本文引用的文献

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Racial disparity in distant recurrence-free survival in patients with localized breast cancer: A pooled analysis of National Surgical Adjuvant Breast and Bowel Project trials.局部乳腺癌患者远处无复发生存的种族差异:国家外科辅助乳腺和肠道项目试验的汇总分析。
Cancer. 2022 Jul 15;128(14):2728-2735. doi: 10.1002/cncr.34241. Epub 2022 May 17.
2
Racial/Ethnic Differences and Trends in Pathologic Complete Response Following Neoadjuvant Chemotherapy for Breast Cancer.乳腺癌新辅助化疗后病理完全缓解的种族/民族差异及趋势
Cancers (Basel). 2022 Jan 21;14(3):534. doi: 10.3390/cancers14030534.
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Calling Attention to the Role of Race-Driven Societal Determinants of Health on Aggressive Tumor Biology: A Focus on Black Americans.呼吁关注种族驱动的社会健康决定因素在侵袭性肿瘤生物学中的作用:以美国黑人为重点。
JCO Oncol Pract. 2022 Jan;18(1):15-22. doi: 10.1200/OP.21.00297. Epub 2021 Jul 13.
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Race and Genetic Ancestry in Medicine - A Time for Reckoning with Racism.医学中的种族与遗传血统——正视种族主义的时刻
N Engl J Med. 2021 Feb 4;384(5):474-480. doi: 10.1056/NEJMms2029562. Epub 2021 Jan 6.
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