Sostman H D, Zoghbi S S, Carbo P, Lord P F
Invest Radiol. 1987 Mar;22(3):216-22. doi: 10.1097/00004424-198703000-00006.
The effect of coumadin treatment upon the uptake of 111In platelets (111In-P) in dogs by experimental jugular thrombi and intravascular catheters was studied. Coumadin, in doses sufficient to raise the PT to the "therapeutic" range, did not impair scintigraphic visualization of thrombi on images obtained 4 hours after 111In-P injection. In addition, there was no obvious effect upon postmortem measurements of thrombus:blood or catheter:blood 111In activity ratios, consistent with the imaging data. However, slight delay in 111In-P accumulation on thrombi and catheters appeared to be present in dogs treated with coumadin, based on images obtained at 1, 2, and 3 hours after 111In-P injection. It is unlikely that coumadin's effect upon 111In-P uptake by thrombi would be significant in a clinical setting, although further studies would be required to confirm this.
研究了香豆素治疗对犬实验性颈静脉血栓和血管内导管摄取111铟标记血小板（111In-P）的影响。给予足以使凝血酶原时间（PT）升至“治疗”范围的香豆素剂量，在注射111In-P后4小时获得的图像上，并未损害血栓的闪烁显像。此外，对血栓的尸检测量结果显示，血栓:血液或导管:血液的111In活度比没有明显影响，这与成像数据一致。然而，根据注射111In-P后1、2和3小时获得的图像，接受香豆素治疗的犬的血栓和导管上111In-P的积累似乎略有延迟。尽管需要进一步研究来证实，但在临床环境中，香豆素对血栓摄取111In-P的影响可能并不显著。
