铜催化苄叉环丙烷的氢氨甲酰化反应：γ,δ-不饱和酰胺的合成。
Copper-catalyzed hydroaminocarbonylation of benzylidenecyclopropanes: synthesis of γ,δ-unsaturated amides.
机构信息
Leibniz-Institut für Katalyse e.V., Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023, Dalian, Liaoning, China.
出版信息
Chem Commun (Camb). 2022 Jun 1;58(45):6534-6537. doi: 10.1039/d2cc02301f.
Herein, we have developed a copper-catalyzed hydroaminocarbonylation of benzylidenecyclopropanes under relatively mild conditions. A series of γ,δ-unsaturated amides with a broad range of functional groups were obtained in moderate to good yields. Both dialkyl-substituted and monoalkyl-substituted hydroxylamine derivatives can be applied in this transformation to give the corresponding tertiary and secondary amides successfully.
在此，我们在相对温和的条件下开发了铜催化的亚苄基环丙烷的氢氨甲酰化反应。一系列具有广泛官能团的γ,δ-不饱和酰胺以中等至良好的收率得到。该转化可以应用二烷基取代和单烷基取代的羟胺衍生物，成功地得到相应的叔胺和仲胺酰胺。
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