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基于单分子钌（II）配合物的近红外二区荧光探针用于增强化学-光热治疗。

A single-molecular ruthenium(II) complex-based NIR-II fluorophore for enhanced chemo-photothermal therapy.

机构信息

Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.

Hubei Key Laboratory for Processing and Application of Catalytic Materials, Huanggang Normal University, Huanggang, 438000, China.

出版信息

Chem Commun (Camb). 2022 Jun 1;58(45):6546-6549. doi: 10.1039/d2cc00082b.

DOI:10.1039/d2cc00082b
PMID:35579558
Abstract

Novel NIR-II Ru(II) polypyridyl fluorophore Ru-1 dots for synergistic chemo-photothermal therapy against 4T1 tumors were designed and synthesized. Guided by NIR-II fluorescence imaging, the synergistic therapeutic efficacy, intracellular delivery, and biodistribution of the Ru-1 dots were precisely tracked in real-time.

摘要

新型近红外二区 Ru(II) 金属卟啉荧光团 Ru-1 点用于协同化学-光热治疗 4T1 肿瘤的设计与合成。在近红外二区荧光成像的指导下，实时精确跟踪了 Ru-1 点的协同治疗效果、细胞内传递和体内分布。

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