• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

比利时列日省的血红蛋白D-洛杉矶型[β121(GH4)谷氨酸→谷氨酰胺]

Hemoglobin D-Los Angeles [beta 121(GH4)Glu----Gln] in the Province of Liège, Belgium.

作者信息

Husquinet H, Parent M T, Schoos-Barbette S, Dodinval-Versie J, Lambotte C, Galacteros F

出版信息

Hemoglobin. 1986;10(6):587-92. doi: 10.3109/03630268609036563.

DOI:10.3109/03630268609036563
PMID:3557993
Abstract

Since 1975, more than 19,000 persons have been tested for hemoglobin abnormalities in Liège. Nine unrelated carriers of Hb D-Los Angeles were discovered. They were of Belgian origin. The family of the ninth index case was studied thoroughly. In six generations, 372 descendants of a couple married in 1818 were recorded. Of the 93 tested, 31 were carriers of the Hb D variant. The complete pedigree indicates that Hb D-Los Angeles was already present in Liege province in the 18th century. A connection with India is unlikely.

摘要

自1975年以来,列日已有超过19000人接受了血红蛋白异常检测。发现了9名不相关的血红蛋白D-洛杉矶携带者。他们是比利时血统。对第九例索引病例的家族进行了全面研究。在六代人中,记录了1818年结婚的一对夫妇的372名后代。在接受检测的93人中,有31人是血红蛋白D变体的携带者。完整的家谱表明,18世纪时列日省就已存在血红蛋白D-洛杉矶。与印度的关联不太可能。

相似文献

1
Hemoglobin D-Los Angeles [beta 121(GH4)Glu----Gln] in the Province of Liège, Belgium.比利时列日省的血红蛋白D-洛杉矶型[β121(GH4)谷氨酸→谷氨酰胺]
Hemoglobin. 1986;10(6):587-92. doi: 10.3109/03630268609036563.
2
Analysis of the population genetic structure of Hb D-Los Angeles [β121 (GH4) Glu→Gln GAA→CAA] in Denizli, Turkey; genetic diversity, historical demography and estimation of the mutation rates based on haplotype variation.土耳其代尼兹利地区Hb D-洛杉矶型[β121(GH4)谷氨酸→谷氨酰胺,GAA→CAA]的群体遗传结构分析;基于单倍型变异的遗传多样性、历史人口统计学及突变率估计
Am J Hum Biol. 2016 Jul;28(4):476-83. doi: 10.1002/ajhb.22816. Epub 2015 Dec 17.
3
Genetic origin of Hb D-Los Angeles [beta121(GH4)Glu-->Gln, GAA-->CAA] according to the beta-globin gene cluster haplotypes.根据β-珠蛋白基因簇单倍型分析Hb D-洛杉矶型[β121(GH4)谷氨酸→谷氨酰胺,GAA→CAA]的遗传起源。
Hemoglobin. 2007;31(3):387-91. doi: 10.1080/03630260701459416.
4
Hb Cleveland or alpha 2 beta 2(93)(F9)Cys----Arg;121(GH4)Glu----Gln.
Hemoglobin. 1991;15(4):269-78. doi: 10.3109/03630269109027879.
5
Hb D-Agri [beta9(A6)Ser --> Tyr;beta121(GH4)Glu --> Gln]: a new Indian hemoglobin variant with two amino acid substitutions in the same beta chain.血红蛋白D-阿格里[β9(A6)位丝氨酸→酪氨酸;β121(GH4)位谷氨酸→谷氨酰胺]:一种新的印度血红蛋白变体,在同一条β链上有两个氨基酸替换。
Hemoglobin. 2001 Aug;25(3):317-21. doi: 10.1081/hem-100105225.
6
Time estimations by network of beta globin gene cluster haplotypes linked with Hb D-Los Angeles [β121 (GH4) Glu → Gln GAA → CAA] mutation in the world populations.通过与世界人群中血红蛋白D - 洛杉矶[β121(GH4)谷氨酸→谷氨酰胺 GAA→CAA]突变相关的β珠蛋白基因簇单倍型网络进行时间估计。
Mol Genet Genomic Med. 2018 Nov;6(6):1181-1187. doi: 10.1002/mgg3.499. Epub 2018 Nov 11.
7
Hb St. Francis [beta 121(GH4)Glu----Gly]: a new mutation at the same site as Hb D-Los Angeles.
Hemoglobin. 1991;15(1-2):115-7. doi: 10.3109/03630269109072491.
8
DNA polymorphisms associated with Hb D-Los Angeles [beta 121(GH4)Glu-->Gln] in southern Italy.
Hemoglobin. 1993 Feb;17(1):9-17. doi: 10.3109/03630269308998881.
9
The beta-globin gene haplotypes associated with Hb D-Los Angeles [beta121(GH4)Glu --> Gln] in Western Iran.与伊朗西部 Hb D-洛杉矶 [β121(GH4)谷氨酸→谷氨酰胺] 相关的β-珠蛋白基因单倍型。
Hemoglobin. 2006;30(1):39-44. doi: 10.1080/03630260500454105.
10
Hb Beograd [beta121(GH4)Glu-->Val, GAA-->GTA] in the Turkish population.土耳其人群中的血红蛋白贝ograd [β121(GH4)谷氨酸→缬氨酸,GAA→GTA]
Hemoglobin. 2007;31(4):491-3. doi: 10.1080/03630260701590335.

引用本文的文献

1
Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis.血红蛋白D-旁遮普型:起源、分布及实验室诊断
Rev Bras Hematol Hemoter. 2015 Mar-Apr;37(2):120-6. doi: 10.1016/j.bjhh.2015.02.007. Epub 2015 Feb 23.
2
Allele frequency of VNTR locus D1S80 observed in Hb D-Los Angeles carrires.观察到在 Hb D-Los Angeles 携带者中 VNTR 位点 D1S80 的等位基因频率。
Mol Biol Rep. 2012 Dec;39(12):10747-50. doi: 10.1007/s11033-012-1966-4. Epub 2012 Oct 7.
3
Molecular characterization of hemoglobin D Punjab traits and clinical-hematological profile of the patients.
血红蛋白D旁遮普特征的分子特征及患者的临床血液学概况。
Sao Paulo Med J. 2012;130(4):248-51. doi: 10.1590/s1516-31802012000400008.