Medical Physics, Radiology Department, Complutense University, Madrid, Spain.
Medical Physics and Radiation Protection Service, Fuenlabrada University Hospital, Fuenlabrada, Spain.
J Appl Clin Med Phys. 2022 Aug;23(8):e13654. doi: 10.1002/acm2.13654. Epub 2022 May 17.
The aim of this work is to study a new analytical model which describes the dose-response curve in megavoltage photon beams of the radiochromic EBT3 film measured with two commercially available flatbed scanners. This model takes into account the different increase of the number of two types of absorbents in the film with absorbed dose and it allows to identify parameters that depend on the flatbed scanner and the film model, and parameters that exclusively depend on the production lot. In addition, the new model is also compared with other models commonly used in the literature in terms of its performance in reducing systematic calibration uncertainties.
The new analytical model consists on a linear combination of two saturating exponential functions for every color channel. The exponents modeling the growing of each kind of absorbent are film model and scanner model-dependent, but they do not depend on the manufacturing lot. The proposed model considers the different dose kinetics of each absorbent and the apparent effective behavior of one of the absorbents in the red color channel of the scanner. The dose-response curve has been measured using EBT3 films, a percentage depth dose (PDD) calibration method in a dose range between 0.5 and 25 Gy, and two flatbed scanners: a Microtek 1000 XL and an EPSON 11000 XL. The PDD calibration method allows to obtain a dense collection of calibration points which have been fitted to the proposed response curve model and to other published models. The fit residuals were used to evaluate the performance of each model compared with the new analytical model.
The model presented here does not introduce any systematic deviations up to the degree of accuracy reached in this work. The residual distribution is normally shaped and with lower variance than the distributions of the other published models. The model separates the parameters reflecting specific characteristics of the dosimetry system from the linear parameters which depend only on the production lot and are related to the relative abundance of each type of absorbent. The calibration uncertainty is reduced by a mean factor of two by using this model compared with the other studied models.
The proposed model reduces the calibration uncertainty related to systematic deviations introduced by the response curve. In addition, it separates parameters depending on the flatbed scanner and the film model from those depending on the production lot exclusively and therefore provides a better characterization of the dosimetry system and increases its reliability.
本工作旨在研究一种新的分析模型,用于描述 EBT3 光致变色胶片在两种市售平板扫描仪中测量的兆伏级光子束的剂量响应曲线。该模型考虑了胶片中两种吸收剂随吸收剂量增加的不同数量增加,并允许确定依赖于平板扫描仪和胶片模型的参数,以及仅依赖于生产批次的参数。此外,新模型还与文献中常用的其他模型进行了比较,以评估其在降低系统校准不确定性方面的性能。
新的分析模型由每个颜色通道的两个饱和指数函数的线性组合组成。建模每种吸收剂增长的指数是胶片模型和扫描仪模型相关的,但不依赖于生产批次。所提出的模型考虑了每种吸收剂的不同剂量动力学以及扫描仪红色通道中一种吸收剂的表观有效行为。使用 EBT3 胶片、在 0.5 至 25 Gy 剂量范围内的百分深度剂量 (PDD) 校准方法以及两种平板扫描仪:Microtek 1000 XL 和 EPSON 11000 XL 测量剂量响应曲线。PDD 校准方法允许获得密集的校准点集合,这些校准点已拟合到所提出的响应曲线模型和其他已发表的模型中。拟合残差用于评估每个模型与新分析模型相比的性能。
本文提出的模型在本工作达到的精度范围内不会引入任何系统偏差。残差分布呈正态形状,方差低于其他已发表模型的分布。该模型将反映剂量测量系统特定特征的参数与仅依赖于生产批次且与每种类型吸收剂相对丰度相关的线性参数区分开来。与其他研究模型相比,使用该模型可将校准不确定性降低约 2 倍。
所提出的模型降低了与响应曲线引入的系统偏差相关的校准不确定性。此外,它将依赖于平板扫描仪和胶片模型的参数与仅依赖于生产批次的参数区分开来,从而更好地描述了剂量测量系统并提高了其可靠性。