Hopkins Brett Andrew, Zavesky Blane, White Derick
Corteva Agriscience Discovery Chemistry, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States.
J Org Chem. 2022 Jun 3;87(11):7547-7550. doi: 10.1021/acs.joc.2c00574. Epub 2022 May 17.
A palladium-catalyzed cross-coupling of thioacetates and aryl halides is described herein. Using a catalyst screening kit, BuBrettPhos Pd G3 was found to be a unique catalyst for this reaction, affording the desired thioarene products in high yields under mild reaction conditions. The thioacetate starting materials are readily available, allowing for quick access to these more lab friendly reagents. Reactions described herein range from the late-stage coupling of complex thioacetates to the first report of a mild set of conditions for thiomethylation of aryl halides.
本文描述了钯催化硫代乙酸酯与芳基卤化物的交叉偶联反应。使用催化剂筛选试剂盒，发现BuBrettPhos Pd G3是该反应的独特催化剂，在温和的反应条件下能高产率地得到所需的硫代芳烃产物。硫代乙酸酯起始原料容易获得，使得能够快速获得这些对实验室更友好的试剂。本文所述反应范围从复杂硫代乙酸酯的后期偶联到芳基卤化物硫甲基化温和条件的首次报道。
