van Schilt Kaz L J, Hollander Evert-Jan F, Koelemay Mark J, van Geloven Anna A W, Olthof Dominique C
Department of Surgery, Tergooi hospital, Hilversum, The Netherlands.
Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Vascular. 2023 Oct;31(5):961-967. doi: 10.1177/17085381221102813. Epub 2022 May 17.
The Hyperview® is a hyperspectral camera, which can be used to assess the microcirculation of patients with peripheral arterial disease (PAD) and/or diabetes mellitus (DM). It measures local tissue oxygenation in concentrations of oxyhemoblobin (OXY), deoxyhemoglobin (DEOXY), and O-saturation (O2-SAT) in arbitrary units. The aim of this validation study is to assess whether the Hyperview® is able to monitor microcirculatory changes after revascularization in patients with PAD.
In this prospective observational cohort study, 50 patients with PAD were included who were scheduled for endovascular, hybrid, or open revascularization. The ankle-brachial index (ABI), systolic toe pressure (TP) (in case of DM), and a set of Hyperview® measurements of the plantar region were recorded before and after treatment. Changes in pre- and postoperative measurements were assessed with the paired t-test.
Some 38 patients underwent endovascular revascularization and eight patients underwent hybrid or open vascular surgical revascularization. After revascularization, the ABI improved from 0.58 to 0.80 ( < 0.001). OXY increased from 72.6 to 77.8 ( = 0.134). DEOXY decreased from 69.1 to 55.0 ( < 0.001). O2-SAT increased from 51.3 to 58.1 ( < 0.001). TP improved from 50.6 to 61.9 mmHg ( = 0.065) but was measured in only 16 patients.
The Hyperview® is able to observe changes in the microcirculation after revascularization in terms of DEOXY and O2-SAT. The results of this study are a promising step into the validation of the Hyperview®.
Hyperview®是一款高光谱相机，可用于评估外周动脉疾病（PAD）和/或糖尿病（DM）患者的微循环。它以任意单位测量氧合血红蛋白（OXY）、脱氧血红蛋白（DEOXY）和氧饱和度（O2-SAT）的局部组织氧合情况。本验证研究的目的是评估Hyperview®能否监测PAD患者血管重建术后的微循环变化。
在这项前瞻性观察性队列研究中，纳入了50例计划接受血管内、杂交或开放血管重建术的PAD患者。记录治疗前后的踝臂指数（ABI）、收缩期趾压（TP）（糖尿病患者）以及足底区域的一组Hyperview®测量值。采用配对t检验评估术前和术后测量值的变化。
约38例患者接受了血管内血管重建术，8例患者接受了杂交或开放血管外科血管重建术。血管重建术后，ABI从0.58提高到0.80（<0.001）。OXY从72.6增加到77.8（=0.134）。DEOXY从69.1降至55.0（<0.001）。O2-SAT从51.3增加到58.1（<0.001）。TP从50.6提高到61.9 mmHg（=0.065），但仅在16例患者中测量。
Hyperview®能够观察血管重建术后DEOXY和O2-SAT方面的微循环变化。本研究结果是Hyperview®验证方面有前景的一步。
