Department of Ophthalmology (G.A.A., E.A., H.K.), Adıyaman University Research and Training Hospital, Adıyaman, Turkey ; Department of Ophthalmology (C.I.), Tayfur Ata Sokmen Medicine Faculty, Mustafa Kemal University, Hatay,Turkey; Department of Pathology (B.P.), Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey ; and Department of Pediatric Endocrinology (S.B.), Adıyaman University Research and Training Hospital,Adıyaman, Turkey.
Eye Contact Lens. 2022 Jul 1;48(7):289-294. doi: 10.1097/ICL.0000000000000903. Epub 2022 May 17.
The aim of this study was to investigate tear function-associated clinical findings and conjunctival histopathological changes in children with vitamin D (Vit-D) deficiency.
This study used a prospective case-control design. Group 1 (n=38) comprised pediatric patients with Vit-D deficiency, and group 2 (n=45) was the control group. Tear break-up times (TBUTs), Schirmer-1 test measurements, ocular surface disease index (OSDI) scores, and conjunctival impression cytology (CIC) results of the groups were compared.
The participant demographic characteristics, including the mean age and the male-to-female ratio, were similar (P>0.05). The median TBUT and Schirmer-1 test measurement were 10 s (5-15) and 12 mm (6-19) in group 1 and 11 s (6-16) and 15 mm (8-21) in group 2 (P=0.004 and P=0.013, respectively). The median OSDI scores were 16 (10-20) in group 1 and 17 (10-21) in group 2 (P=0.092). According to the CIC, 25 samples in group 1 and 40 samples in group 2 were categorized as grade 0, 11 samples in group 1 and 5 samples in group 2 were categorized as grade 1, and 2 samples in group 1 and no sample in group 2 were categorized as grade 2 (P=0.027).
Significant conjunctival histopathological changes occur in children with Vit-D deficiency, and these changes have effects on some tear function-associated clinical findings including the Schirmer-1 test and TBUT measurements.
本研究旨在探讨维生素 D（Vit-D）缺乏症患儿的泪液功能相关临床发现和结膜组织病理学变化。
本研究采用前瞻性病例对照设计。第 1 组（n=38）为 Vit-D 缺乏症患儿，第 2 组（n=45）为对照组。比较两组的泪膜破裂时间（TBUT）、Schirmer 试验测量值、眼表疾病指数（OSDI）评分和结膜印迹细胞学（CIC）结果。
两组参与者的人口统计学特征，包括平均年龄和男女比例，相似（P>0.05）。第 1 组的中位数 TBUT 和 Schirmer 试验测量值分别为 10 秒（5-15）和 12 毫米（6-19），第 2 组分别为 11 秒（6-16）和 15 毫米（8-21）（P=0.004 和 P=0.013）。第 1 组的中位数 OSDI 评分为 16（10-20），第 2 组为 17（10-21）（P=0.092）。根据 CIC，第 1 组 25 个样本和第 2 组 40 个样本为 0 级，第 1 组 11 个样本和第 2 组 5 个样本为 1 级，第 1 组 2 个样本和第 2 组无样本为 2 级（P=0.027）。
Vit-D 缺乏症患儿存在明显的结膜组织病理学变化，这些变化会影响一些泪液功能相关的临床发现，包括 Schirmer 试验和 TBUT 测量值。
