Evans M L, Graham M M, Mahler P A, Rasey J S
Int J Radiat Oncol Biol Phys. 1987 Apr;13(4):563-7. doi: 10.1016/0360-3016(87)90072-1.
A quantitative measure of the vascular permeability surface area product (PS) for albumin has been made using a double isotope technique. PS was significantly elevated in irradiated rat lung, heart, skin, and muscle, between 19 and 26 days following 18 or 25 Gray thorax irradiation. Administration of dexamethasone from 2 days before irradiation through the day of measurement suppressed the expected increase in PS in lung, heart, and muscle, but not in skin. Shorter periods of steroid administration were not as effective in suppressing this response to radiation exposure. Increased vascular permeability following radiation may be an essential element in the development of radiation fibrosis. We hypothesize that the ability to suppress this response could result in a long term reduction in the incidence of fibrosis.
采用双同位素技术对白蛋白的血管通透性表面积乘积（PS）进行了定量测量。在18或25格雷胸部照射后19至26天，照射大鼠的肺、心脏、皮肤和肌肉中的PS显著升高。从照射前2天至测量当天给予地塞米松可抑制肺、心脏和肌肉中PS的预期升高，但对皮肤无效。较短时间的类固醇给药在抑制这种辐射暴露反应方面效果不佳。辐射后血管通透性增加可能是放射性纤维化发展的一个关键因素。我们推测，抑制这种反应的能力可能会导致纤维化发生率的长期降低。
