成人非糖尿病患者血糖谱的老化。

Aging of glucose profiles in an adult population without diabetes.

机构信息

Faculty of Nursing, University of Santiago de Compostela, Santiago de Compostela, Spain; Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain; Research Methods (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

Faculty of Nursing, University of Santiago de Compostela, Santiago de Compostela, Spain.

出版信息

Diabetes Res Clin Pract. 2022 Jun;188:109929. doi: 10.1016/j.diabres.2022.109929. Epub 2022 May 14.

DOI:10.1016/j.diabres.2022.109929

PMID:35580705

Abstract

AIMS

This study aimed to determine the effect of aging on glucose profiles in a population without diabetes.

METHODS

We investigated the evolution of glucose profiles in an adult population without diabetes using continuous glucose monitoring (CGM) in two periods separated by 5 years. Anthropometrics, laboratory tests (HbA1c, fasting blood glucose) and CGM data (mean glycemia level, coefficient of variation, time in range) were measured in both periods to study the change in values over time.

RESULTS

125 participants (68% women) mean age 43.1 ± 12.4 years and classified as normoglycemic at baseline were included. Of the total population 15.2% had worsened glycemic status after 5 years, age and baseline glucose values (HbA1c and percentage of values above 175 mg/dL) were the variables related with this change. Related to CGM, we found that after 5 years there was a decrease in the percentage of values between 70 and 99 mg/dl (45.0% to 38.7%, p = 0.002) and an increase in the 100-139 mg/dL range (52.9% to 57.5% p = 0.016).

CONCLUSIONS

Our results indicate that in an adult population without diabetes there are changes in glucose profiles with aging highlighting the reduction of blood glucose values below 100 mg/dL.

摘要

目的

本研究旨在确定在无糖尿病人群中，年龄对血糖谱的影响。

方法

我们使用连续血糖监测（CGM）在两个相隔 5 年的时期内研究无糖尿病的成年人群的血糖谱演变。在两个时期测量了人体测量学、实验室检查（HbA1c、空腹血糖）和 CGM 数据（平均血糖水平、变异系数、达标时间），以研究随时间变化的数值变化。

结果

共纳入 125 名（68%为女性）年龄为 43.1±12.4 岁、基线时血糖正常的参与者。在总人群中，15.2%的人在 5 年后血糖状况恶化，年龄和基线血糖值（HbA1c 和高于 175mg/dL 的血糖值百分比）是与这种变化相关的变量。与 CGM 相关，我们发现 5 年后，70-99mg/dl 之间的血糖值百分比下降（45.0%至 38.7%，p=0.002），100-139mg/dl 之间的血糖值百分比增加（52.9%至 57.5%，p=0.016）。