Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
Sci Rep. 2023 Aug 26;13(1):13987. doi: 10.1038/s41598-023-40949-1.
Continuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the reproducibility of CGM data remains limited. The present work examines the reproducibility of the results provided by a CGM system in a random sample of a free-living adult population, from a functional data analysis approach. Functional intraclass correlation coefficients (ICCs) and their 95% confidence intervals (CI) were calculated to assess the reproducibility of CGM results in 581 individuals. 62% were females 581 participants (62% women) mean age 48 years (range 18-87) were included, 12% had previously been diagnosed with diabetes. The inter-day reproducibility of the CGM results was greater for subjects with diabetes (ICC 0.46 [CI 0.39-0.55]) than for normoglycaemic subjects (ICC 0.30 [CI 0.27-0.33]); the value for prediabetic subjects was intermediate (ICC 0.37 [CI 0.31-0.42]). For normoglycaemic subjects, inter-day reproducibility was poorer among the younger (ICC 0.26 [CI 0.21-0.30]) than the older subjects (ICC 0.39 [CI 0.32-0.45]). Inter-day reproducibility was poorest among normoglycaemic subjects, especially younger normoglycaemic subjects, suggesting the need to monitor some patient groups more often than others.
连续血糖监测系统 (CGM) 是了解不同情况下和不同人群中血糖行为的非常有用的工具。尽管 CGM 系统在临床实践和研究中得到了广泛应用，但我们对 CGM 数据的可重复性的理解仍然有限。本研究从功能数据分析的角度，考察了随机抽取的自由生活成年人群中 CGM 系统结果的可重复性。在 581 名参与者中计算了功能组内相关系数 (ICC)及其 95%置信区间 (CI)，以评估 CGM 结果的可重复性。581 名参与者中 62%为女性（581 名参与者中有 62%为女性），平均年龄为 48 岁（范围为 18-87 岁），12%之前被诊断患有糖尿病。糖尿病患者的 CGM 结果的日内可重复性大于血糖正常者（ICC 0.46 [CI 0.39-0.55]），而低于糖尿病前期患者（ICC 0.37 [CI 0.31-0.42]）。对于血糖正常者，年轻组（ICC 0.26 [CI 0.21-0.30]）的日内可重复性比老年组（ICC 0.39 [CI 0.32-0.45]）差。血糖正常者的日内可重复性最差，尤其是年轻的血糖正常者，这表明需要比其他人群更频繁地监测一些患者群体。
