Singapore National Eye Centre, Singapore; Singapore Eye Research Institute, Singapore.
Singapore National Eye Centre, Singapore; Singapore Eye Research Institute, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore; Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Ophthalmol Retina. 2022 Nov;6(11):1080-1088. doi: 10.1016/j.oret.2022.05.010. Epub 2022 May 14.
To describe the normative quantitative parameters of the macular retinal vasculature, as well as their systemic and ocular associations using OCT angiography (OCTA).
Population-based, cross-sectional study.
Adults aged > 50 years were recruited from the third examination of the population-based Singapore Malay Eye Study.
All participants underwent a standardized comprehensive examination and spectral-domain OCTA (Optovue) of the macula. OCT angiography scans that revealed pre-existing retinal disease, revealed macular pathology, and had poor quality were excluded.
The normative quantitative vessel densities of the superficial layer, deep layer, and foveal avascular zone (FAZ) were evaluated. Ocular and systemic associations with macular retinal vasculature parameters were also evaluated in a multivariable analysis using linear regression models with generalized estimating equation models.
We included 1184 scans (1184 eyes) of 749 participants. The mean macular superficial vessel density (SVD) and deep vessel density (DVD) were 45.1 ± 4.2% (95% confidence interval [CI], 37.8%-51.4%) and 44.4 ± 5.2% (95% CI, 36.9%-53.2%), respectively. The mean SVD and DVD were highest in the superior quadrant (48.7 ± 5.9%) and nasal quadrant (52.7 ± 4.6%), respectively. The mean FAZ area and perimeter were 0.32 ± 0.11 mm (95% CI, 0.17-0.51 mm) and 2.14 ± 0.38 mm (95% CI, 1.54-2.75 mm), respectively. In the multivariable regression analysis, female sex was associated with higher SVD (β = 1.25, P ≤ 0.001) and DVD (β = 0.75, P = 0.021). Older age (β = -0.67, P < 0.001) was associated with lower SVD, whereas longer axial length (β = -0.42, P = 0.003) was associated with lower DVD. Female sex, shorter axial length, and worse best-corrected distance visual acuity were associated with a larger FAZ area. No association of a range of systemic parameters with vessel density was found.
This study provided normative macular vasculature parameters in an adult Asian population, which may serve as reference values for quantitative interpretation of OCTA data in normal and disease states.
描述使用 OCT 血管造影术（OCTA）的黄斑视网膜血管的规范定量参数及其与全身和眼部的关系。
基于人群的横断面研究。
从基于人群的新加坡马来人眼部研究的第三次检查中招募了年龄大于 50 岁的成年人。
所有参与者均接受了标准化的全面检查和黄斑的光谱域 OCTA（Optovue）。排除了先前存在视网膜疾病、黄斑病理学和质量差的 OCT 血管造影扫描。
评估浅层、深层和黄斑无血管区（FAZ）的规范定量血管密度。使用广义估计方程模型的多元线性回归模型评估了与黄斑视网膜血管参数相关的眼部和全身关联。
我们纳入了 749 名参与者的 1184 个扫描（1184 只眼）。平均黄斑浅层血管密度（SVD）和深层血管密度（DVD）分别为 45.1±4.2%（95%置信区间[CI]，37.8%-51.4%）和 44.4±5.2%（95% CI，36.9%-53.2%）。SVD 和 DVD 最高的平均值分别是上象限（48.7±5.9%）和鼻象限（52.7±4.6%）。平均 FAZ 面积和周长分别为 0.32±0.11mm（95% CI，0.17-0.51mm）和 2.14±0.38mm（95% CI，1.54-2.75mm）。在多元回归分析中，女性与更高的 SVD（β=1.25，P≤0.001）和 DVD（β=0.75，P=0.021）相关。年龄较大（β=-0.67，P<0.001）与 SVD 降低相关，而眼轴较长（β=-0.42，P=0.003）与 DVD 降低相关。女性、较短的眼轴和较差的最佳矫正远视力与更大的 FAZ 面积相关。没有发现系统参数范围与血管密度相关的关联。
本研究提供了亚洲成年人黄斑血管的规范参数，可为正常和疾病状态下 OCTA 数据的定量解释提供参考值。
