Department of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Graefes Arch Clin Exp Ophthalmol. 2023 Dec;261(12):3589-3597. doi: 10.1007/s00417-023-06137-7. Epub 2023 Jun 22.
To compare the patterns of retinal microvasculature change in the peripapillary and macular region between compressive optic neuropathy (CON) and glaucomatous optic neuropathy (GON), and to assess the ability of optical coherence tomography angiography (OCTA) in differentiating the two conditions.
This cross-sectional study included 108 participants (108 eyes), 36 with CON, 36 with GON, and 36 healthy controls. The CON and GON eyes were matched by the average peripapillary retinal nerve fiber layer (pRNFL) thickness (1:1). Optical coherence tomography (OCT) and OCTA were performed to compare the structural and vascular change of the peripapillary and macular region between groups.
Both CON and GON eyes showed more severe structural and vascular damage than the control eyes. The CON eyes had lower pRNFL thickness than the GON eyes in the temporal and nasal quadrants, and thicker pRNFL thickness in the inferior quadrant. The average GCC thickness did not differ between the two groups. The peripapillary vessel density of the CON group was significantly higher in the inferior sectors than that of the GON group. In the macular region, the CON group had significantly higher vessel density in the whole image, the temporal sector in parafovea region, and the temporal, superior, and inferior sectors in perifovea region.
To a similar degree of structural damage, CON had less retinal vascular impairment than GON, especially in the macular region, and the significance of the finding needs further evaluation.
比较压迫性视神经病变（CON）和青光眼性视神经病变（GON）的视盘周围和黄斑区视网膜微血管变化模式，并评估光相干断层扫描血管造影（OCTA）在区分这两种情况的能力。
这项横断面研究纳入了 108 名参与者（108 只眼），其中 36 只眼患有 CON，36 只眼患有 GON，36 只眼为健康对照。通过平均视盘周围视网膜神经纤维层（pRNFL）厚度（1:1）对 CON 和 GON 眼进行匹配。比较各组之间视盘周围和黄斑区的结构和血管变化。
CON 和 GON 眼的结构和血管损伤均比对照组更严重。在颞侧和鼻侧象限，CON 眼的 pRNFL 厚度比 GON 眼更薄，而在下象限，CON 眼的 pRNFL 厚度更厚。两组的平均 GCC 厚度无差异。CON 组视盘周围血管密度在下象限显著高于 GON 组。在黄斑区，CON 组的全像、旁中心凹颞侧区、中心凹旁颞侧、上侧和下侧区的血管密度均显著升高。
在相似程度的结构损伤下，CON 的视网膜血管损伤程度低于 GON，尤其是在黄斑区，这一发现的意义需要进一步评估。
