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Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study.

作者信息

García-Martín Paloma, Díez Ana Moñiz, Maldonado José Manuel Sánchez, Serrano Antonio José Cabrera, Ter Horst Rob, Benavente Yolanda, Landi Stefano, Macauda Angelica, Clay-Gilmour Alyssa, Hernández-Mohedo Francisca, Niazi Yasmeen, González-Sierra Pedro, Espinet Blanca, Rodríguez-Sevilla Juan José, Maffei Rossana, Blanco Gonzalo, Giaccherini Matteo, Puiggros Anna, Cerhan James, Marasca Roberto, Cañadas-Garre Marisa, López-Nevot Miguel Ángel, Chen-Liang Tzu, Thomsen Hauke, Gámez Irene, Moreno Víctor, Marcos-Gragera Rafael, García-Álvarez María, Llorca Javier, Jerez Andrés, Berndt Sonja, Butrym Aleksandra, Norman Aaron D, Casabonne Delphine, Luppi Mario, Slager Susan L, Hemminki Kari, Li Yang, Alcoceba Miguel, Campa Daniele, Canzian Federico, de Sanjosé Silvia, Försti Asta, Netea Mihai G, Jurado Manuel, Sainz Juan

机构信息

Hospital Campus de la Salud, PTS Granada, Granada, Spain.

Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, Spain.

出版信息

Blood Cancer J. 2022 May 17;12(5):79. doi: 10.1038/s41408-022-00676-8.

DOI:10.1038/s41408-022-00676-8
PMID:35581176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9114372/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24a/9114372/dd62f956e370/41408_2022_676_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24a/9114372/dd62f956e370/41408_2022_676_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24a/9114372/dd62f956e370/41408_2022_676_Fig1_HTML.jpg

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本文引用的文献

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Front Oncol. 2021 Jul 1;11:698572. doi: 10.3389/fonc.2021.698572. eCollection 2021.
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Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.全基因组关联研究鉴定出进展性慢性淋巴细胞白血病的风险位点。
Nat Commun. 2021 Jan 28;12(1):665. doi: 10.1038/s41467-020-20822-9.
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Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients.
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J Transl Med. 2018 Jun 20;16(1):172. doi: 10.1186/s12967-018-1545-0.
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Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment.腺苷信号传导介导慢性淋巴细胞白血病微环境中的缺氧反应。
Blood Adv. 2016 Nov 22;1(1):47-61. doi: 10.1182/bloodadvances.2016000984. eCollection 2016 Nov 29.
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