Brown C J, Abbas P J
Hear Res. 1987;25(2-3):193-204. doi: 10.1016/0378-5955(87)90091-8.
AP and ABR tuning curves were measured using a forward masking paradigm in guinea pigs with chronically implanted electrodes. Measurements were made before exposure to wide-band noise and at several intervals after exposure. The noise exposure was sufficient to produce temporary threshold shifts up to 60 dB lasting several days. Results showed similar reductions in Q10, tip-to-tail ratio and slope of simultaneously recorded AP and ABR tuning curves as a function of threshold shift following noise exposure. Tuning curves based on changes in response latency are presented as well as tuning curves based on changes in response amplitude. AP and ABR latency tuning curves showed similar form and changes with hearing loss as amplitude tuning curves. The similarities between AP and ABR tuning characteristics provide evidence that the ABR is sensitive enough to peripheral changes to be useful as a tool to study auditory frequency selectivity. The similarities between amplitude and latency tuning characteristics suggest that information regarding frequency selectivity of the auditory system can be obtained using response latency as well as response amplitude.
使用正向掩蔽范式，对长期植入电极的豚鼠测量动作电位（AP）和听性脑干反应（ABR）调谐曲线。在暴露于宽带噪声之前以及暴露后的几个时间间隔进行测量。噪声暴露足以产生高达60 dB的暂时阈移，持续数天。结果表明，噪声暴露后，随着阈移，同时记录的AP和ABR调谐曲线的Q10、头尾比和斜率出现类似程度的降低。呈现了基于反应潜伏期变化的调谐曲线以及基于反应幅度变化的调谐曲线。AP和ABR潜伏期调谐曲线与幅度调谐曲线一样，具有相似的形式且随听力损失而变化。AP和ABR调谐特性之间的相似性提供了证据，表明ABR对外周变化足够敏感，可用作研究听觉频率选择性的工具。幅度和潜伏期调谐特性之间的相似性表明，关于听觉系统频率选择性的信息可以通过反应潜伏期以及反应幅度来获得。
