Wang Jingjing, Zhang Jialiang, Yu Shuling, Wu Wei, Jiang Xiqun
Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
ACS Macro Lett. 2013 Jan 15;2(1):82-85. doi: 10.1021/mz300538u. Epub 2012 Dec 31.
Giant multiarm polymers with and without β-cyclodextrin (β-CD) end groups were synthesized. Further, the former was assembled into nanoparticles via a β-CD/adamantane inclusion complex. The incorporation of an esterase-sensitive linker in the inclusion complex enables the nanoparticles to decompose to the multiarm polymer again through the hydrolysis of ester linkage, making the nanoparticles have the characteristics of multistage nanovectors.
合成了带有和不带有β-环糊精（β-CD）端基的巨型多臂聚合物。此外，前者通过β-CD/金刚烷包合物组装成纳米颗粒。在包合物中引入酯酶敏感连接体，使纳米颗粒能够通过酯键水解再次分解为多臂聚合物，从而使纳米颗粒具有多级纳米载体的特性。
