Girek Tomasz, Koziel Kinga, Girek Beata, Ciesielski Wojciech
Faculty of Mathematics and Natural Science, Jan Dlugosz University in Czestochowa, Armii Krajowej Ave., 13/15, 42 201 Czestochowa, Poland.
Polymers (Basel). 2020 Nov 29;12(12):2845. doi: 10.3390/polym12122845.
Water soluble highly anionic β-cyclodextrin-based polymers were synthesized by reaction between cyclodextrin oxyanion and pyromellitic anhydride. The synthesis method utilizes activation hydroxyl groups in anhydrous glucopyranosyl units (AGU) in the DMF solution with the use of NaH. In these conditions, like in the case of the cyclodextrin reactions in the highly alkaline media, there is a nucleophilic substitution of difunctional compounds, which develops a polymer network with various cyclodextrin substitution. Different molar ratios of the reagents were investigated in terms of molecular size, chemical structure and water solubility of the polymers. The separation of the polymer due to particle size by ultrafiltration process and HPSEC-MALLS-RI and MALDI-TOF MS measurements for molecular mass analysis were employed. The IR, H NMR, SEM, DSC and TG measurements were taken for the structural characterization of the polymers. Additionally, the solubility test and metal ion complexation processes were also investigated in a wide range of pH. These polymers could be used in several areas such as: improving the aqueous solubility of poor water-soluble molecules, removing heavy metals from waste water, protecting degradable substances or synthesizing new drug delivery systems.
通过环糊精氧阴离子与均苯四甲酸酐反应合成了水溶性高阴离子β-环糊精基聚合物。该合成方法利用NaH在DMF溶液中活化无水吡喃葡萄糖基单元（AGU）中的羟基。在这些条件下，就像在高碱性介质中环糊精反应的情况一样，双官能化合物会发生亲核取代，从而形成具有各种环糊精取代度的聚合物网络。研究了不同试剂摩尔比对聚合物分子大小、化学结构和水溶性的影响。采用超滤法根据粒径分离聚合物，并通过HPSEC-MALLS-RI和MALDI-TOF MS测量进行分子量分析。对聚合物进行了红外光谱（IR）、核磁共振氢谱（H NMR）、扫描电子显微镜（SEM）、差示扫描量热法（DSC）和热重分析法（TG）测量以进行结构表征。此外，还在广泛的pH范围内研究了溶解度测试和金属离子络合过程。这些聚合物可用于多个领域，例如：提高难溶性分子的水溶性、从废水中去除重金属、保护可降解物质或合成新的药物递送系统。
