Zhou Chuncai, Wang Mingzhi, Zou Kaidian, Chen Jing, Zhu Yunqing, Du Jianzhong
School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai, 201804, China.
ACS Macro Lett. 2013 Nov 19;2(11):1021-1025. doi: 10.1021/mz400480z. Epub 2013 Nov 1.
Antibacterial polypeptides as ancient immune defense systems are effective against bacteria. Here we report a novel kind of "armed" carrier: an antibacterial polypeptide-grafted chitosan-based nanocapsule with an excellent antibacterial efficacy against both Gram-positive and Gram-negative bacteria. This nanocapsule also has excellent blood compatibility and low cytotoxicity. Patients after tumor surgery may benefit from this "armed" carrier because it is highly anti-inflammation and is able to deliver anticancer and antiepileptic drugs simultaneously.
抗菌多肽作为古老的免疫防御系统，对细菌有效。在此，我们报道了一种新型的“武装”载体：一种抗菌多肽接枝的壳聚糖基纳米胶囊，对革兰氏阳性菌和革兰氏阴性菌均具有优异的抗菌效果。这种纳米胶囊还具有优异的血液相容性和低细胞毒性。肿瘤手术后的患者可能会从这种“武装”载体中受益，因为它具有高度的抗炎性，并且能够同时递送抗癌和抗癫痫药物。
