Koriem Khaled Mohamed Mohamed
Department of Medical Physiology, National Research Centre, Giza 12622, Egypt.
World J Hepatol. 2022 Mar 27;14(3):535-550. doi: 10.4254/wjh.v14.i3.535.
Bisphenol A (BPA) is present in many plastic products and food packaging. On the other hand, fertaric acid (FA) is a hydroxycinnamic acid.
To investigate the effect of FA on BPA-related liver, kidney, and testis toxicity, DNA breakdown, and histopathology in male rats.
Thirty male albino rats were divided into five equal groups (6 rats/group): Control, paraffin oil, FA-, BPA-, and FA + BPA-treated groups. The control and paraffin oil groups were administered orally with 1 mL distilled water and 1 mL paraffin oil, respectively. The FA-, BPA-, and FA+ BPA-treated groups were administered orally with FA (45 mg/kg, bw) dissolved in 1 mL distilled water, BPA (4 mg/kg, bw) dissolved in 1 mL paraffin oil, and FA (45 mg/kg, bw) followed by BPA (4 mg/kg, bw), respectively. All these treatments were given once a day for 6 wk.
BPA induced a significant decrease in serum alkaline phosphatase, acid phosphatase, sodium, potassium and chloride, testosterone, dehydroepiandrosterone sulfate, glucose-6-phosphate dehydrogenase, 3β-hydroxysteroid dehydrogenase, and testis protein levels but a highly significant increase in serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase, lactate dehydrogenase, bilirubin, urea, creatinine, uric acid, luteinizing hormone, follicle stimulating hormone, sex hormone binding globulin, blood urea nitrogen, and testis cholesterol levels. Also, FA inhibited the degradation of liver, kidney, and testis DNA content. Oral administration of FA to BPA-treated rats restored all the above parameters to normal levels.
FA ameliorates BPA-induced liver, kidney, and testis toxicity, DNA breakdown, and histopathological changes.
双酚A（BPA）存在于许多塑料制品和食品包装中。另一方面，阿魏酸（FA）是一种羟基肉桂酸。
研究阿魏酸对雄性大鼠BPA相关的肝脏、肾脏和睾丸毒性、DNA断裂及组织病理学的影响。
将30只雄性白化大鼠分为五组，每组6只：对照组、石蜡油组、阿魏酸处理组、BPA处理组和阿魏酸+BPA处理组。对照组和石蜡油组分别口服1 mL蒸馏水和1 mL石蜡油。阿魏酸处理组、BPA处理组和阿魏酸+BPA处理组分别口服溶解于1 mL蒸馏水中的阿魏酸（45 mg/kg，体重）、溶解于1 mL石蜡油中的BPA（4 mg/kg，体重）以及先给予阿魏酸（45 mg/kg，体重）后给予BPA（4 mg/kg，体重）。所有这些处理均每天进行一次，持续6周。
BPA导致血清碱性磷酸酶、酸性磷酸酶、钠、钾、氯、睾酮、硫酸脱氢表雄酮、葡萄糖-6-磷酸脱氢酶、3β-羟基类固醇脱氢酶和睾丸蛋白水平显著降低，但血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶、γ-谷氨酰转肽酶、乳酸脱氢酶、胆红素、尿素、肌酐、尿酸、黄体生成素、卵泡刺激素、性激素结合球蛋白、血尿素氮和睾丸胆固醇水平显著升高。此外，阿魏酸抑制肝脏、肾脏和睾丸DNA含量的降解。对BPA处理的大鼠口服阿魏酸可使上述所有参数恢复至正常水平。
阿魏酸可改善BPA诱导的肝脏、肾脏和睾丸毒性、DNA断裂及组织病理学变化。
