Kumar Shashank, Kushwaha Prem Prakash, Gupta Sanjay
School of Basic and Applied Sciences, Department of Biochemistry and Microbial Sciences, Central University of Punjab, Bathinda 151001, India.
Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Cancer Drug Resist. 2019 Jun 19;2(2):161-177. doi: 10.20517/cdr.2018.27. eCollection 2019.
Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment. Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways. Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes. This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.
耐药性是一种复杂的现象，在癌症治疗期间经常作为化疗失败而出现。恶性细胞通过不同的机制和途径越来越多地对各种化疗药物产生耐药性。了解耐药性所涉及的分子机制仍然是一个重要的研究领域，用于确定精确的靶点和发现药物以改善治疗效果。本综述强调了一些最近出现的靶点和途径在驱动耐药性方面所起的关键作用。
