Das Abhijit, Bhattacharya Barshana, Roy Souvik
Department of Pharmacology, NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata 700053, India.
Genes Dis. 2022 Feb 22;9(4):868-888. doi: 10.1016/j.gendis.2021.12.025. eCollection 2022 Jul.
Cancer is one of those leading diseases worldwide, which takes millions of lives every year. Researchers are continuously looking for specific approaches to eradicate the deadly disease, ensuring minimal adverse effects along with more therapeutic significance. Targeting of different aberrantly regulated signaling pathways, involved in cancer, is surely one of the revolutionary chemotherapeutic approach. In this instance, GSK3 and PI3K signaling cascades are considered as important role player for both the oncogenic activation and inactivation which further leads to cancer proliferation and metastasis. In this review, we have discussed the potential role of GSK3 and PI3K signaling in cancer, and we further established the crosstalk between PI3K and GSK3 signaling, through showcasing their cross activation, cross inhibition and convergence pathways in association with cancer. We also exhibited the effect of GSK3 on the efficacy of PI3K inhibitors to overcome the drug resistance and preventing the cell proliferation, metastasis in a combinatorial way with GSK3 inhibitors for a better treatment strategy in clinical settings.
癌症是全球主要疾病之一，每年夺走数百万人的生命。研究人员不断寻找根除这种致命疾病的特定方法，确保在具有更大治疗意义的同时将副作用降至最低。针对参与癌症的不同异常调节信号通路进行靶向治疗，无疑是一种革命性的化疗方法。在这种情况下，GSK3和PI3K信号级联被认为是致癌激活和失活的重要参与者，这进一步导致癌症增殖和转移。在这篇综述中，我们讨论了GSK3和PI3K信号在癌症中的潜在作用，并通过展示它们与癌症相关的交叉激活、交叉抑制和汇聚途径，进一步确立了PI3K和GSK3信号之间的相互作用。我们还展示了GSK3对PI3K抑制剂疗效的影响，以克服耐药性，并与GSK3抑制剂联合使用，以防止细胞增殖和转移，从而在临床环境中制定更好的治疗策略。
