Department of Nephrology, Hemodialysis, Apheresis, and Kidney Transplantation, Grenoble University Hospital, Grenoble, France.
Grenoble Alpes University, Grenoble, France.
Ther Apher Dial. 2023 Feb;27(1):159-169. doi: 10.1111/1744-9987.13885. Epub 2022 May 28.
Cryoglobulinemia is defined as the presence of an abnormal immunoglobulin that may be responsible for vasculitis of small-caliber vessels. Apheresis can be used in order to temporarily eliminate circulating cryoglobulins. The aim of this study was to assess the effectiveness of apheresis (double-filtration plasmapheresis-DFPP-) in symptomatic and/or severe cryoglobulinemias.
Four male patients presenting cryoglobulinemic vasculitis and who received DFPP sessions were included.
Their mean age was 57 ± 15 years. One patient had hepatitis-C virus (HCV)-related cryoglobulinemia and the other three patients were carriers of an IgM Kappa monoclonal gammopathy. Mean duration of follow-up was 15 ± 2 months. DFPP allowed healing of ulcerative skin lesions in the first patient and remission of nephrotic syndrome in the other patients after a median of 6(5-10) sessions.
DFPP can be used safely in cryoglobulinemic-vasculitis and can be considered early to achieve a faster and sustained clinical-biological response.
冷球蛋白血症定义为存在异常免疫球蛋白，可能导致小血管血管炎。可以采用血浆置换（双重滤过血浆置换-DFPP-）来暂时清除循环冷球蛋白。本研究旨在评估血浆置换（双重滤过血浆置换-DFPP-）在有症状和/或严重冷球蛋白血症中的疗效。
纳入了 4 名患有冷球蛋白血症血管炎并接受 DFPP 治疗的男性患者。
他们的平均年龄为 57±15 岁。1 名患者为丙型肝炎病毒（HCV）相关冷球蛋白血症，另外 3 名患者为 IgM Kappa 单克隆丙种球蛋白血症携带者。中位随访时间为 15±2 个月。DFPP 使第 1 名患者的溃疡性皮肤病变愈合，其他 3 名患者的肾病综合征在 6（5-10）次治疗后缓解。
DFPP 可安全用于冷球蛋白血症血管炎，可早期应用以获得更快和持续的临床-生物学反应。
