贝塔-D-葡聚糖检测作为侵袭性真菌感染诊断途径的一部分能否降低抗真菌治疗费用？
Can Beta-D-Glucan testing as part of the diagnostic pathway for invasive fungal infection reduce anti-fungal treatment costs?
机构信息
Critical Care Department, Royal Liverpool University Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8XP, United Kingdom.
Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 8TX, United Kingdom.
出版信息
Med Mycol. 2022 May 28;60(5). doi: 10.1093/mmy/myac034.
UNLABELLED
We performed a cost comparison of the current diagnostic and treatment pathway for invasive fungal infection (IFI) versus a proposed pathway that incorporates Beta-D-Glucan (BDG) testing from the NHS perspective. A fungal pathogen was identified in 58/107 (54.2%) patients treated with systemic anti-fungals in the Critical Care Department. Mean therapy duration was 23 days (standard deviation [SD] = 22 days), and cost was £5590 (SD = £7410) per patient. Implementation of BDG tests in the diagnostic and treatment pathway of patients with suspected IFI could result in a mean saving of £1643 per patient should a result be returned within 2 days.
LAY SUMMARY
Invasive fungal infection increases the risk of death in very sick people. So, treatment is started before test results are known. Beta-D-Glucan (BDG) test is faster than standard blood culture tests. We estimate that using BDG tests in how patients are diagnosed could save about £1643 per patient.
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我们从英国国家医疗服务体系（NHS）的角度，对侵袭性真菌感染（IFI）的现行诊断和治疗方案与纳入β-D-葡聚糖（BDG）检测的拟议方案进行了成本比较。在重症监护病房接受全身性抗真菌治疗的 107 名患者中，有 58/107（54.2%）名患者的真菌病原体得到了鉴定。平均治疗持续时间为 23 天（标准差 [SD] = 22 天），每位患者的费用为 5590 英镑（SD = 7410 英镑）。如果在 2 天内获得检测结果，在疑似 IFI 患者的诊断和治疗路径中实施 BDG 检测，每位患者的平均节省费用为 1643 英镑。
概述
侵袭性真菌感染会增加重病患者的死亡风险。因此，在获得检测结果之前就开始治疗。β-D-葡聚糖（BDG）检测比标准血液培养检测更快。我们估计，在患者的诊断中使用 BDG 检测可以为每位患者节省约 1643 英镑。
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