Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China.
Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China.
Nutr Cancer. 2022;74(9):3340-3350. doi: 10.1080/01635581.2022.2077386. Epub 2022 May 18.
The association between meat intake and hepatocellular carcinoma (HCC) risk is still unclear. We conducted a meta-analysis with observational studies to clarify this relationship. A total of 17 studies involving 2,915,680 participants and 4,953 cases of HCC were included in the meta-analysis. Ten studies reported red meat intake, nine reported white meat intake, nine reported fish intake, seven reported processed meat intake, and five reported total meat intake. The results showed that the consumption of red meat (relative risk [RR] = 1.04; 95% confidence interval [CI]: 0.91-1.18; I=50.50%; = 0.033) and total meat intake (RR = 1.01; 95% CI: 0.90-1.13; I = 15.50%; = 0.316) were not associated with risk of HCC. However, a higher dietary intake of processed meat (RR = 1.20; 95% CI: 1.02-1.41; I = 26.30%; = 0.228) may increase the risk of HCC. In contrast, the intake of white meat (RR = 0.76; 95% CI: 0.63-0.92; I = 68.30%; = 0.001) and fish (RR = 0.91; 95% CI: 0.86-0.96; I =40.90%; = 0.095) were inversely associated with risk of HCC. Our findings suggest that dietary intervention may be an effective approach to preventing HCC. These need to be verified with further well-designed observational studies and experimental clinical research.
肉类摄入与肝细胞癌（HCC）风险之间的关联尚不清楚。我们进行了一项荟萃分析，纳入了观察性研究，以阐明这种关系。该荟萃分析共纳入了 17 项研究，涉及 2915680 名参与者和 4953 例 HCC 病例。其中 10 项研究报告了红肉摄入量，9 项报告了白肉摄入量，9 项报告了鱼类摄入量，7 项报告了加工肉摄入量，5 项报告了总肉摄入量。结果表明，摄入红肉（相对风险 [RR] = 1.04；95%置信区间 [CI]：0.91-1.18；I = 50.50%； = 0.033）和总肉摄入量（RR = 1.01；95% CI：0.90-1.13；I = 15.50%； = 0.316）与 HCC 风险无关。然而，较高的加工肉类摄入量（RR = 1.20；95% CI：1.02-1.41；I = 26.30%； = 0.228）可能会增加 HCC 的风险。相比之下，摄入白肉（RR = 0.76；95% CI：0.63-0.92；I = 68.30%； = 0.001）和鱼类（RR = 0.91；95% CI：0.86-0.96；I = 40.90%； = 0.095）与 HCC 风险呈负相关。我们的研究结果表明，饮食干预可能是预防 HCC 的有效方法。这些需要通过进一步设计良好的观察性研究和实验临床研究来验证。
